Adrenergic and dopaminergic control of the canine paw microcirculation

Eric D. Endean, Sunil K. Mukhopadhyay, Lit K. Fung, Jack L. Cronenwett, James C. Stanley, S. Martin Lindenauer

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Basal isolated canine paw blood flow was equally distributed between arteriovenous anastomosis (AVA) and capillary circulations. Norepinephrine decreased AVA flow by 92% and capillary flow by 41%. Dopamine significantly reduced AVA flow by 94% compared to baseline with a 37% reduction in capillary flow. However, with α-adrenergic blockade dopamine decreased AVA flow 66% while capillary flow increased 42%. Isoproterenol increased capillary flow almost twofold and appeared to decrease AVA flow, although the latter was statistically insignificant. Differential effects of adrenergic and dopaminergic agonists on canine paw AVA and capillary blood flow suggest the existence of independent regulation of these components of the microcirculation.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalJournal of Surgical Research
Issue number1
StatePublished - Jan 1986

ASJC Scopus subject areas

  • Surgery


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