Purpose. We recently reported an association of adult BMI change with colon cancer risk. Here, we sought to further explore this association with respect to postmenopausal HRT use in a larger study population. Methods. We included 1,457 postmenopausal women participating in an ongoing population-based case-control study of colon cancer. Results. We confirmed a previously reported association of adulthood weight gain and increased risk of colon cancer: compared to those with 5 kg/m2 change of BMI, women who reported moderate (510 kg/m2) and large (>10 kg/m2) BMI changes since their 20s had OR estimates of 1.54 (95 CI = 1.092.19) and 1.45 (95 CI = 0.902.33), respectively (P for trend = 0.05). Stratified analyses showed that this association was limited to HRT nonusers: ORs were 1.77 (95 CI = 1.023.05) and 2.21 (95 CI = 1.094.45), respectively (P for trend = 0.03), for BMI changes occurring between the 20s decade and time of recruitment among non-users. Similar associations were observed for BMI changes since the 30s decade. There was no association among HRT users. Conclusion. Our results suggest early adulthood weight gain increases colon cancer risk in postmenopausal women who do not use HRT.
|Journal||Journal of Obesity|
|State||Published - 2012|
Bibliographical noteFunding Information:
This work was partially supported by an unconditional fellowship awarded by Sanofi-Aventis, and by grants from Instituto de Salud Carlos III (Red HERACLES RD06/0009 and CIBERESP).
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism