Adult Moyamoya Disease and Syndrome: Current Perspectives and Future Directions: A Scientific Statement from the American Heart Association/American Stroke Association

Nestor R. Gonzalez, Sepideh Amin-Hanjani, Oh Young Bang, Christopher Coffey, Rose Du, Jorn Fierstra, Justin F. Fraser, Satoshi Kuroda, Gretchen E. Tietjen, Shadi Yaghi

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

Adult moyamoya disease and syndrome are rare disorders with significant morbidity and mortality. A writing group of experts was selected to conduct a literature search, summarize the current knowledge on the topic, and provide a road map for future investigation. The document presents an update in the definitions of moyamoya disease and syndrome, modern methods for diagnosis, and updated information on pathophysiology, epidemiology, and both medical and surgical treatment. Despite recent advancements, there are still many unresolved questions about moyamoya disease and syndrome, including lack of unified diagnostic criteria, reliable biomarkers, better understanding of the underlying pathophysiology, and stronger evidence for treatment guidelines. To advance progress in this area, it is crucial to acknowledge the limitations and weaknesses of current studies and explore new approaches, which are outlined in this scientific statement for future research strategies.

Original languageEnglish
Pages (from-to)E465-E479
JournalStroke
Volume54
Issue number10
DOIs
StatePublished - Oct 1 2023

Bibliographical note

Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.

Keywords

  • AHA Scientific Statements
  • cerebral revascularization
  • diagnosis
  • guidelines as topic
  • hemorrhagic stroke
  • moyamoya disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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