Advances in computational fluid mechanics in cellular flow manipulation: A review

Masoud Arabghahestani, Sadegh Poozesh, Nelson K. Akafuah

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Recently, remarkable developments have taken place, leading to significant improvements in microfluidic methods to capture subtle biological effects down to single cells. As microfluidic devices are getting sophisticated, design optimization through experimentations is becoming more challenging. As a result, numerical simulations have contributed to this trend by offering a better understanding of cellular microenvironments hydrodynamics and optimizing the functionality of the current/emerging designs. The need for new marketable designs with advantageous hydrodynamics invokes easier access to efficient as well as time-conservative numerical simulations to provide screening over cellular microenvironments, and to emulate physiological conditions with high accuracy. Therefore, an excerpt overview on how each numerical methodology and associated handling software works, and how they differ in handling underlying hydrodynamic of lab-on-chip microfluidic is crucial. These numerical means rely on molecular and continuum levels of numerical simulations. The current review aims to serve as a guideline for researchers in this area by presenting a comprehensive characterization of various relevant simulation techniques.

Original languageEnglish
Article number4041
JournalApplied Sciences (Switzerland)
Issue number19
StatePublished - Oct 1 2019

Bibliographical note

Funding Information:
This research was funded internally by the University of Kentucky, Institute of Research for Technology Development (IR4TD). This research received no external funding.

Publisher Copyright:
© 2019 by the authors.


  • Cellular flow
  • Computational fluid mechanics
  • Microfluidic devices
  • Molecular and continuum levels
  • Numerical simulations

ASJC Scopus subject areas

  • General Materials Science
  • Instrumentation
  • General Engineering
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes


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