Advances in the structure of phosphodiesterase 2 and selective inhibitors

Zhao Xinyun, Chen Xi, Zhan Changguo

Research output: Contribution to journalArticlepeer-review


Phosphodiesterase 2 (PDE2) is mainly distributed in brain and heart cells. PDE2 is a potential drug target that plays an important role to maintain the level of intracellular second messengers cAMP and cGMP through PDE2-catalyzed hydrolysis of cAMP and cGMP. Selective inhibitors of PDE2 are expected to be valuable in improving permeability of endothelial cells and memory. In this article, the physiological function, distribution, and characteristics of the regulatory and catalytic domains, as well as some selective inhibitors against PDE2 are reviewed. Finally, based on the trend of the drug design, future design of PDE2 inhibitors is also prospected.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalChinese Journal of Organic Chemistry
Issue number2
StatePublished - Feb 2009


  • Catalytic domain
  • Enzyme distribution
  • Enzyme function
  • Phosphodiesterase 2 (PDE2)
  • Regulatory domain
  • Selective inhibitor

ASJC Scopus subject areas

  • Organic Chemistry


Dive into the research topics of 'Advances in the structure of phosphodiesterase 2 and selective inhibitors'. Together they form a unique fingerprint.

Cite this