Advances in the use of regulatory T-cells for the prevention and therapy of Graft-vs.-Host disease

Reshma Ramlal, Gerhard C. Hildebrandt

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Regulatory T (Tregs) cells play a crucial role in immunoregulation and promotion of immunological tolerance. Adoptive transfer of these cells has therefore been of interest in the field of bone marrow and solid organ transplantation, autoimmune diseases and allergy medicine. In bone marrow transplantation, Tregs play a pivotal role in the prevention of graft-verus-host disease (GvHD). This has generated interest in using adoptive Treg cellular therapy in the prevention and treatment of GvHD. There have been several barriers to the feasibility of Treg cellular therapy in the setting of hematopoietic stem cell transplantation (HSCT) which include low Treg concentration in peripheral blood, requiring expansion of the Treg population; instability of the expanded product with loss of FoxP3 expression; and issues related to the purity of the expanded product. Despite these challenges, investigators have been able to successfully expand these cells both in vivo and in vitro and have demonstrated that they can be safely infused in humans for the prevention and treatment of GvHD with no increase in relapse risk or infections risk.

Original languageEnglish
Article number23
JournalBiomedicines
Volume5
Issue number2
DOIs
StatePublished - Jun 1 2017

Bibliographical note

Publisher Copyright:
© 2017 by the authors.

Keywords

  • Adoptive cellular therapy
  • CD4+CD25+FoxP3+ T cells
  • Graft versus host disease (GvHD)
  • Tregs

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Biochemistry, Genetics and Molecular Biology

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