TY - JOUR
T1 - Advancing the study of stroke in women
T2 - Summary and recommendations for future research from an NINDS-sponsored multidisciplinary working group
AU - Bushnell, Cheryl D.
AU - Hurn, Patricia
AU - Colton, Carol
AU - Miller, Virginia M.
AU - Del Zoppo, Gregory
AU - Elkind, Mitchell S.V.
AU - Stern, Barney
AU - Herrington, David
AU - Ford-Lynch, Gwendolyn
AU - Gorelick, Philip
AU - James, Andra
AU - Brown, Candice M.
AU - Choi, Emily
AU - Bray, Paul
AU - Newby, L. Kristin
AU - Goldstein, Larry B.
AU - Simpkins, James
PY - 2006/9
Y1 - 2006/9
N2 - BACKGROUND AND PURPOSE - Women have poorer outcomes from stroke than men. Women also have risk factors that are unique, including pregnancy and hormone therapy. Hormone therapy for postmenopausal replacement increased the risk of ischemic stroke according to results of the Women's Health Initiative clinical trials. Based on the current understanding of the mechanisms of action of estrogen, the reasons for this increased risk are uncertain. One method to better understand the reasons for this increased risk is to re-evaluate estrogen's role in the neurovascular unit, simplistically comprised of the neurons, glia, and endothelial cells, as well as the processes of inflammation, and hemostasis/thrombosis. Besides the role of estrogen there are many gaps of knowledge about issues specific to women and stroke. SUMMARY OF REVIEW - A multidisciplinary workshop was held in August 2005 to summarize the current evidence for estrogen and, more generally, stroke in women, and to provide recommendations for future basic, preclinical, and clinical research studies. CONCLUSIONS - These studies may ultimately change the approach to stroke prevention and treatment in women.
AB - BACKGROUND AND PURPOSE - Women have poorer outcomes from stroke than men. Women also have risk factors that are unique, including pregnancy and hormone therapy. Hormone therapy for postmenopausal replacement increased the risk of ischemic stroke according to results of the Women's Health Initiative clinical trials. Based on the current understanding of the mechanisms of action of estrogen, the reasons for this increased risk are uncertain. One method to better understand the reasons for this increased risk is to re-evaluate estrogen's role in the neurovascular unit, simplistically comprised of the neurons, glia, and endothelial cells, as well as the processes of inflammation, and hemostasis/thrombosis. Besides the role of estrogen there are many gaps of knowledge about issues specific to women and stroke. SUMMARY OF REVIEW - A multidisciplinary workshop was held in August 2005 to summarize the current evidence for estrogen and, more generally, stroke in women, and to provide recommendations for future basic, preclinical, and clinical research studies. CONCLUSIONS - These studies may ultimately change the approach to stroke prevention and treatment in women.
KW - Estrogen
KW - Minority groups
KW - Stroke
KW - Women
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U2 - 10.1161/01.STR.0000236053.37695.15
DO - 10.1161/01.STR.0000236053.37695.15
M3 - Review article
C2 - 16857945
AN - SCOPUS:33748355616
SN - 0039-2499
VL - 37
SP - 2387
EP - 2399
JO - Stroke
JF - Stroke
IS - 9
ER -