Aedes aegypti males as vehicles for insecticide delivery

Corey L. Brelsfoard; James W. Mains; Steve Mulligan; Anthony Cornel; Jodi Holeman; Susanne Kluh; Andrea Leal; Lawrence J. Hribar; Harold Morales; Tanya Posey; Stephen L. Dobson

doi:10.3390/insects10080230

Aedes aegypti males as vehicles for insecticide delivery

Corey L. Brelsfoard, James W. Mains, Steve Mulligan, Anthony Cornel, Jodi Holeman, Susanne Kluh, Andrea Leal, Lawrence J. Hribar, Harold Morales, Tanya Posey, Stephen L. Dobson

Entomology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Aedes aegypti continues to spread globally and remains a challenge to control, in part due to its ‘cryptic behavior’ in that it often deposits eggs (oviposits) in larval habitats that are difficult to find and treat using traditional methods. Auto-dissemination strategies target these cryptic breeding sites by employing mosquitoes to deliver lethal doses of insecticide. This report describes the initial field trials of an application known as Autodissemination Augmented by Males (ADAM), utilizing A. aegypti males dusted with pyriproxyfen (PPF). Findings presented here are drawn from both caged and field trial studies. Together, these trials examined for the ability of A. aegypti males to disseminate PPF and to impact field populations. PPF-dusted males were able to effectively deliver lethal doses of PPF to oviposition sites under the conditions tested. Results from field trials in Florida and California demonstrated reduced A. aegypti populations in treated areas, compared to areas where PPF-treated males were not released. These results indicate that the release of PPF-dusted A. aegypti males can impact A. aegypti populations as measured by both reduced larval survival and lower numbers of adult female A. aegypti. We propose the ADAM approach as an addition to existing mosquito control techniques targeting A. aegypti and other mosquitoes that utilize cryptic larval habitats.

Original language	English
Article number	230
Journal	Insects
Volume	10
Issue number	8
DOIs	https://doi.org/10.3390/insects10080230
State	Published - Aug 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Funding

Funding: Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number R44AI112048. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This research and technology were supported in part by an award from the Kentucky Cabinet for Economic Development, Office of Entrepreneurship, under the Grant Agreement KSTC-184-512-17-253 with the Kentucky Science and Technology Corporation. Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number R44AI112048. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This research and technology were supported in part by an award from the Kentucky Cabinet for Economic Development, Office of Entrepreneurship, under the Grant Agreement KSTC-184-512-17-253 with the Kentucky Science and Technology Corporation. Acknowledgments: We thank supporting staff at MosquitoMate, Inc., Greater Los Angeles County Vector Control District, Florida Keys Mosquito Control District, and Consolidated Mosquito Abatement District for their technical support.

Funders	Funder number
Kentucky Cabinet for Economic Development
Kentucky Science and Technology Corporation
Office of Entrepreneurship	KSTC-184-512-17-253
National Institutes of Health (NIH)	R44AI112048
Foundation for the National Institutes of Health
National Institute of Allergy and Infectious Diseases

Keywords

Autodissemination
Mosquito control
Pyriproxyfen

ASJC Scopus subject areas

Insect Science

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10.3390/insects10080230

Cite this

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title = "Aedes aegypti males as vehicles for insecticide delivery",

abstract = "Aedes aegypti continues to spread globally and remains a challenge to control, in part due to its {\textquoteleft}cryptic behavior{\textquoteright} in that it often deposits eggs (oviposits) in larval habitats that are difficult to find and treat using traditional methods. Auto-dissemination strategies target these cryptic breeding sites by employing mosquitoes to deliver lethal doses of insecticide. This report describes the initial field trials of an application known as Autodissemination Augmented by Males (ADAM), utilizing A. aegypti males dusted with pyriproxyfen (PPF). Findings presented here are drawn from both caged and field trial studies. Together, these trials examined for the ability of A. aegypti males to disseminate PPF and to impact field populations. PPF-dusted males were able to effectively deliver lethal doses of PPF to oviposition sites under the conditions tested. Results from field trials in Florida and California demonstrated reduced A. aegypti populations in treated areas, compared to areas where PPF-treated males were not released. These results indicate that the release of PPF-dusted A. aegypti males can impact A. aegypti populations as measured by both reduced larval survival and lower numbers of adult female A. aegypti. We propose the ADAM approach as an addition to existing mosquito control techniques targeting A. aegypti and other mosquitoes that utilize cryptic larval habitats.",

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author = "Brelsfoard, \{Corey L.\} and Mains, \{James W.\} and Steve Mulligan and Anthony Cornel and Jodi Holeman and Susanne Kluh and Andrea Leal and Hribar, \{Lawrence J.\} and Harold Morales and Tanya Posey and Dobson, \{Stephen L.\}",

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AU - Mulligan, Steve

AU - Cornel, Anthony

AU - Holeman, Jodi

AU - Kluh, Susanne

AU - Leal, Andrea

AU - Hribar, Lawrence J.

AU - Morales, Harold

AU - Posey, Tanya

AU - Dobson, Stephen L.

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Aedes aegypti males as vehicles for insecticide delivery

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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