Aerosolized amphotericin for the treatment of allergic bronchopulmonary aspergillosis

Don Hayes, Brian S. Murphy, James E. Lynch, David J. Feola

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is a complex hypersensitivity reaction to Aspergillus fumigatus that occur frequently in patients with cystic fibrosis (CF). Recurrent episodes of bronchial obstruction, inflammation, and mucoid impaction occur in ABPA and results in bronchiectasis, fibrosis, and respiratory failure. The treatment of ABPA includes corticosteroids to reduce the acute inflammation and intraconazole to reduce the fungal colonization load in order to reduce lung injury. This case discusses the successful use of aerosolized amphotericin B for the treatment of ABPA in a 14-year-old patient with CF listed for lung transplant. The patient required fewer hospitalizations, and both oral corticosteroids and anti-fungal therapy were eventually stopped. Pediatr Pulmonol. 2010;45:1145-1148.

Original languageEnglish
Pages (from-to)1145-1148
Number of pages4
JournalPediatric Pulmonology
Volume45
Issue number11
DOIs
StatePublished - Nov 2010

Keywords

  • aerosolized
  • allergic bronchopulmonary aspergillosis
  • amphotericin B
  • Aspergillus fumigatus
  • cystic fibrosis
  • inhaled

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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