Abstract
Allergic bronchopulmonary aspergillosis (ABPA) is a complex hypersensitivity reaction to Aspergillus fumigatus that occur frequently in patients with cystic fibrosis (CF). Recurrent episodes of bronchial obstruction, inflammation, and mucoid impaction occur in ABPA and results in bronchiectasis, fibrosis, and respiratory failure. The treatment of ABPA includes corticosteroids to reduce the acute inflammation and intraconazole to reduce the fungal colonization load in order to reduce lung injury. This case discusses the successful use of aerosolized amphotericin B for the treatment of ABPA in a 14-year-old patient with CF listed for lung transplant. The patient required fewer hospitalizations, and both oral corticosteroids and anti-fungal therapy were eventually stopped. Pediatr Pulmonol. 2010;45:1145-1148.
Original language | English |
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Pages (from-to) | 1145-1148 |
Number of pages | 4 |
Journal | Pediatric Pulmonology |
Volume | 45 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2010 |
Keywords
- Aspergillus fumigatus
- aerosolized
- allergic bronchopulmonary aspergillosis
- amphotericin B
- cystic fibrosis
- inhaled
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Pulmonary and Respiratory Medicine