Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys

Feng Yue; Guodong Zhang; Rongping Tang; Zhouquan Zhang; Liqiong Teng; Zhiming Zhang

doi:10.1186/s12944-016-0280-x

Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys

Feng Yue, Guodong Zhang, Rongping Tang, Zhouquan Zhang, Liqiong Teng, Zhiming Zhang

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: The age-related dysfunction of glucose and lipid metabolism has a long-standing relationship with cardiovascular and neurodegenerative disease. However, the effects of metabolic dysfunction on men and women are different. Reasons for these sex differences remains unclear. Cynomolgus monkeys have been used, in the past, for the study of human metabolic diseases due to their biologically proximity to humans. Nevertheless, few studies to date have focused on both age- and sex-related differences in glucose and lipid metabolism. The present study was designed to specifically address these questions by using a large cohort of cynomolgus monkeys (N = 1,399) including 433 males and 966 females with ages ranging 4 to 24 years old. Methods: Fasting plasma glucose (FPG) and lipid parameters including total cholesterol (T-Cho), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. All these parameters were compared between ages and sexes. Results: Among the entire cohort, age was strongly correlated with levels of FPG, TG and HDL. Consequently, sex-related analysis revealed that females had significantly higher average levels of FPG, T-Cho, TG, HDL-C and LDL-C than their male counterparts. In addition, more female (28.5 %) than male (16 %) monkeys qualified for impaired fasting plasma glucose (IFPG). In those IFPG animals, sex-related differences were also detected i.e. females had significantly increased levels of T-Cho, TG and LDL-C. Conclusions: The result, for the first time, demonstrated the similarities and differences in detail between male and female cynomolgus monkeys in relationship to age-related glucose and lipoprotein metabolisms, and differences under various physiological conditions. The detailed glucose and lipoprotein profiling should provide additional and important insights for prediabetic conditions. Cynomolgus monkeys appear to be an excellent model for translational research of diabetes and for novel therapeutic strategies testing to overt diabetes.

Original language	English
Article number	111
Journal	Lipids in Health and Disease
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/s12944-016-0280-x
State	Published - Jun 24 2016

Bibliographical note

Publisher Copyright:
© 2016 The Author(s).

Funding

This study was supported by grants from State High-Tech Development Plan of Ministry of Sciences and Technology of China (2012AA020703), the National Natural Science Foundation of China (31472056), the Projects of Science & Technology Department of Guangxi Province of China (13-29-06, 1347004–20), and the Project of Science & Technology Bureau of Nanning of China (20145194).

Funders	Funder number
Project of Science & Technology Bureau of Nanning of China	20145194
State High-Tech Development Plan of Ministry of Sciences and Technology of China	2012AA020703
National Institutes of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism	R01AA020703
National Natural Science Foundation of China (NSFC)	31472056
Science and Technology Department of Guangxi Zhuang Autonomous	1347004–20, 13-29-06

Keywords

Aging
Cynomolgus monkey
Diabetes
Glucose
Lipoprotein
Sex

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Clinical Biochemistry
Biochemistry, medical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12944-016-0280-x

Cite this

@article{13e7823520eb4947a975b9d6065c743c,

title = "Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys",

abstract = "Background: The age-related dysfunction of glucose and lipid metabolism has a long-standing relationship with cardiovascular and neurodegenerative disease. However, the effects of metabolic dysfunction on men and women are different. Reasons for these sex differences remains unclear. Cynomolgus monkeys have been used, in the past, for the study of human metabolic diseases due to their biologically proximity to humans. Nevertheless, few studies to date have focused on both age- and sex-related differences in glucose and lipid metabolism. The present study was designed to specifically address these questions by using a large cohort of cynomolgus monkeys (N = 1,399) including 433 males and 966 females with ages ranging 4 to 24 years old. Methods: Fasting plasma glucose (FPG) and lipid parameters including total cholesterol (T-Cho), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. All these parameters were compared between ages and sexes. Results: Among the entire cohort, age was strongly correlated with levels of FPG, TG and HDL. Consequently, sex-related analysis revealed that females had significantly higher average levels of FPG, T-Cho, TG, HDL-C and LDL-C than their male counterparts. In addition, more female (28.5 %) than male (16 %) monkeys qualified for impaired fasting plasma glucose (IFPG). In those IFPG animals, sex-related differences were also detected i.e. females had significantly increased levels of T-Cho, TG and LDL-C. Conclusions: The result, for the first time, demonstrated the similarities and differences in detail between male and female cynomolgus monkeys in relationship to age-related glucose and lipoprotein metabolisms, and differences under various physiological conditions. The detailed glucose and lipoprotein profiling should provide additional and important insights for prediabetic conditions. Cynomolgus monkeys appear to be an excellent model for translational research of diabetes and for novel therapeutic strategies testing to overt diabetes.",

keywords = "Aging, Cynomolgus monkey, Diabetes, Glucose, Lipoprotein, Sex",

author = "Feng Yue and Guodong Zhang and Rongping Tang and Zhouquan Zhang and Liqiong Teng and Zhiming Zhang",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

month = jun,

day = "24",

doi = "10.1186/s12944-016-0280-x",

language = "English",

volume = "15",

number = "1",

}

TY - JOUR

T1 - Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys

AU - Yue, Feng

AU - Zhang, Guodong

AU - Tang, Rongping

AU - Zhang, Zhouquan

AU - Teng, Liqiong

AU - Zhang, Zhiming

PY - 2016/6/24

Y1 - 2016/6/24

N2 - Background: The age-related dysfunction of glucose and lipid metabolism has a long-standing relationship with cardiovascular and neurodegenerative disease. However, the effects of metabolic dysfunction on men and women are different. Reasons for these sex differences remains unclear. Cynomolgus monkeys have been used, in the past, for the study of human metabolic diseases due to their biologically proximity to humans. Nevertheless, few studies to date have focused on both age- and sex-related differences in glucose and lipid metabolism. The present study was designed to specifically address these questions by using a large cohort of cynomolgus monkeys (N = 1,399) including 433 males and 966 females with ages ranging 4 to 24 years old. Methods: Fasting plasma glucose (FPG) and lipid parameters including total cholesterol (T-Cho), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. All these parameters were compared between ages and sexes. Results: Among the entire cohort, age was strongly correlated with levels of FPG, TG and HDL. Consequently, sex-related analysis revealed that females had significantly higher average levels of FPG, T-Cho, TG, HDL-C and LDL-C than their male counterparts. In addition, more female (28.5 %) than male (16 %) monkeys qualified for impaired fasting plasma glucose (IFPG). In those IFPG animals, sex-related differences were also detected i.e. females had significantly increased levels of T-Cho, TG and LDL-C. Conclusions: The result, for the first time, demonstrated the similarities and differences in detail between male and female cynomolgus monkeys in relationship to age-related glucose and lipoprotein metabolisms, and differences under various physiological conditions. The detailed glucose and lipoprotein profiling should provide additional and important insights for prediabetic conditions. Cynomolgus monkeys appear to be an excellent model for translational research of diabetes and for novel therapeutic strategies testing to overt diabetes.

AB - Background: The age-related dysfunction of glucose and lipid metabolism has a long-standing relationship with cardiovascular and neurodegenerative disease. However, the effects of metabolic dysfunction on men and women are different. Reasons for these sex differences remains unclear. Cynomolgus monkeys have been used, in the past, for the study of human metabolic diseases due to their biologically proximity to humans. Nevertheless, few studies to date have focused on both age- and sex-related differences in glucose and lipid metabolism. The present study was designed to specifically address these questions by using a large cohort of cynomolgus monkeys (N = 1,399) including 433 males and 966 females with ages ranging 4 to 24 years old. Methods: Fasting plasma glucose (FPG) and lipid parameters including total cholesterol (T-Cho), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. All these parameters were compared between ages and sexes. Results: Among the entire cohort, age was strongly correlated with levels of FPG, TG and HDL. Consequently, sex-related analysis revealed that females had significantly higher average levels of FPG, T-Cho, TG, HDL-C and LDL-C than their male counterparts. In addition, more female (28.5 %) than male (16 %) monkeys qualified for impaired fasting plasma glucose (IFPG). In those IFPG animals, sex-related differences were also detected i.e. females had significantly increased levels of T-Cho, TG and LDL-C. Conclusions: The result, for the first time, demonstrated the similarities and differences in detail between male and female cynomolgus monkeys in relationship to age-related glucose and lipoprotein metabolisms, and differences under various physiological conditions. The detailed glucose and lipoprotein profiling should provide additional and important insights for prediabetic conditions. Cynomolgus monkeys appear to be an excellent model for translational research of diabetes and for novel therapeutic strategies testing to overt diabetes.

KW - Aging

KW - Cynomolgus monkey

KW - Diabetes

KW - Glucose

KW - Lipoprotein

KW - Sex

UR - http://www.scopus.com/inward/record.url?scp=84975865027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975865027&partnerID=8YFLogxK

U2 - 10.1186/s12944-016-0280-x

DO - 10.1186/s12944-016-0280-x

M3 - Article

C2 - 27342143

AN - SCOPUS:84975865027

SN - 1476-511X

VL - 15

JO - Lipids in Health and Disease

JF - Lipids in Health and Disease

IS - 1

M1 - 111

ER -

Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this