Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus

D. L. Sparks, W. R. Markesbery, J. T. Slevin

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Levels of monoamines and metabolites in rostral and caudal hypothalamic fragments of young (3-4 months) and old (25-26 months) Fischer 344-rats were compared. There were no differences between fragments of young animals. In senescent rats, 5-hydroxyindoleacetic acid (5HIAA) increased in both rostral and caudal hypothalamus. The ratio 5HIAA/5HT (serotonin), an index of serotonin turnover, increased only rostrally. This age-related increase of 5HIAA/5HT in rostral hypothalamus was associated with a decrease in [3H]-spiperone binding. There were no age-related changes of MAO-A activity in the hypothalamus or of serum tyrosine or tryptophan levels.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalNeurobiology of Aging
Issue number3
StatePublished - 1985

Bibliographical note

Funding Information:
We thank Audrey Nedsen for secretarial assistance and Joyce Faro for techmcal assistance We apprecmte comments and cntm-ctsms by Dr Richard Walker who rewewed the manuscript This research was supported m part by NIA 5T32 AGO0084 (D L S ), N1A R01 AG02435 (W R M ), NINCDS (TIDA) NS00732 (J T S ) and the Veterans Administration


  • Aging
  • Hypothalamus
  • MAO-A
  • Serotonin
  • [H]-Spiperone

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology


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