Abstract
Levels of monoamines and metabolites in rostral and caudal hypothalamic fragments of young (3-4 months) and old (25-26 months) Fischer 344-rats were compared. There were no differences between fragments of young animals. In senescent rats, 5-hydroxyindoleacetic acid (5HIAA) increased in both rostral and caudal hypothalamus. The ratio 5HIAA/5HT (serotonin), an index of serotonin turnover, increased only rostrally. This age-related increase of 5HIAA/5HT in rostral hypothalamus was associated with a decrease in [3H]-spiperone binding. There were no age-related changes of MAO-A activity in the hypothalamus or of serum tyrosine or tryptophan levels.
Original language | English |
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Pages (from-to) | 213-217 |
Number of pages | 5 |
Journal | Neurobiology of Aging |
Volume | 6 |
Issue number | 3 |
DOIs | |
State | Published - 1985 |
Bibliographical note
Funding Information:We thank Audrey Nedsen for secretarial assistance and Joyce Faro for techmcal assistance We apprecmte comments and cntm-ctsms by Dr Richard Walker who rewewed the manuscript This research was supported m part by NIA 5T32 AGO0084 (D L S ), N1A R01 AG02435 (W R M ), NINCDS (TIDA) NS00732 (J T S ) and the Veterans Administration
Funding
We thank Audrey Nedsen for secretarial assistance and Joyce Faro for techmcal assistance We apprecmte comments and cntm-ctsms by Dr Richard Walker who rewewed the manuscript This research was supported m part by NIA 5T32 AGO0084 (D L S ), N1A R01 AG02435 (W R M ), NINCDS (TIDA) NS00732 (J T S ) and the Veterans Administration
Funders | Funder number |
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WiPL-D | N1A R01 AG02435 |
NINCDS | |
Veterans Administration | |
National Institute on Aging | 5T32 AGO0084 |
National Institute of Neurological Disorders and Stroke | K07NS000732 |
Titanium Industry Development Association | NS00732 |
Keywords
- Aging
- Hypothalamus
- MAO-A
- Serotonin
- [H]-Spiperone
ASJC Scopus subject areas
- General Neuroscience
- Aging
- Developmental Biology
- Clinical Neurology
- Geriatrics and Gerontology