Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus

D. L. Sparks; W. R. Markesbery; J. T. Slevin

doi:10.1016/0197-4580(85)90052-1

Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus

D. L. Sparks
, W. R. Markesbery
, J. T. Slevin

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Levels of monoamines and metabolites in rostral and caudal hypothalamic fragments of young (3-4 months) and old (25-26 months) Fischer 344-rats were compared. There were no differences between fragments of young animals. In senescent rats, 5-hydroxyindoleacetic acid (5HIAA) increased in both rostral and caudal hypothalamus. The ratio 5HIAA/5HT (serotonin), an index of serotonin turnover, increased only rostrally. This age-related increase of 5HIAA/5HT in rostral hypothalamus was associated with a decrease in [³H]-spiperone binding. There were no age-related changes of MAO-A activity in the hypothalamus or of serum tyrosine or tryptophan levels.

Original language	English
Pages (from-to)	213-217
Number of pages	5
Journal	Neurobiology of Aging
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/0197-4580(85)90052-1
State	Published - 1985

Bibliographical note

Funding Information:
We thank Audrey Nedsen for secretarial assistance and Joyce Faro for techmcal assistance We apprecmte comments and cntm-ctsms by Dr Richard Walker who rewewed the manuscript This research was supported m part by NIA 5T32 AGO0084 (D L S ), N1A R01 AG02435 (W R M ), NINCDS (TIDA) NS00732 (J T S ) and the Veterans Administration

Funding

We thank Audrey Nedsen for secretarial assistance and Joyce Faro for techmcal assistance We apprecmte comments and cntm-ctsms by Dr Richard Walker who rewewed the manuscript This research was supported m part by NIA 5T32 AGO0084 (D L S ), N1A R01 AG02435 (W R M ), NINCDS (TIDA) NS00732 (J T S ) and the Veterans Administration

Funders	Funder number
WiPL-D	N1A R01 AG02435
NINCDS
Veterans Administration
National Institute on Aging	5T32 AGO0084
National Institute of Neurological Disorders and Stroke	K07NS000732
Titanium Industry Development Association	NS00732

Keywords

Aging
Hypothalamus
MAO-A
Serotonin
[H]-Spiperone

ASJC Scopus subject areas

General Neuroscience
Aging
Developmental Biology
Clinical Neurology
Geriatrics and Gerontology

Access to Document

10.1016/0197-4580(85)90052-1

Cite this

@article{9a7017505b784a1dbbf7b293e4df8261,

title = "Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus",

abstract = "Levels of monoamines and metabolites in rostral and caudal hypothalamic fragments of young (3-4 months) and old (25-26 months) Fischer 344-rats were compared. There were no differences between fragments of young animals. In senescent rats, 5-hydroxyindoleacetic acid (5HIAA) increased in both rostral and caudal hypothalamus. The ratio 5HIAA/5HT (serotonin), an index of serotonin turnover, increased only rostrally. This age-related increase of 5HIAA/5HT in rostral hypothalamus was associated with a decrease in [3H]-spiperone binding. There were no age-related changes of MAO-A activity in the hypothalamus or of serum tyrosine or tryptophan levels.",

keywords = "Aging, Hypothalamus, MAO-A, Serotonin, [H]-Spiperone",

author = "Sparks, \{D. L.\} and Markesbery, \{W. R.\} and Slevin, \{J. T.\}",

note = "Funding Information: We thank Audrey Nedsen for secretarial assistance and Joyce Faro for techmcal assistance We apprecmte comments and cntm-ctsms by Dr Richard Walker who rewewed the manuscript This research was supported m part by NIA 5T32 AGO0084 (D L S ), N1A R01 AG02435 (W R M ), NINCDS (TIDA) NS00732 (J T S ) and the Veterans Administration",

year = "1985",

doi = "10.1016/0197-4580(85)90052-1",

language = "English",

volume = "6",

pages = "213--217",

number = "3",

}

TY - JOUR

T1 - Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus

AU - Sparks, D. L.

AU - Markesbery, W. R.

AU - Slevin, J. T.

N1 - Funding Information: We thank Audrey Nedsen for secretarial assistance and Joyce Faro for techmcal assistance We apprecmte comments and cntm-ctsms by Dr Richard Walker who rewewed the manuscript This research was supported m part by NIA 5T32 AGO0084 (D L S ), N1A R01 AG02435 (W R M ), NINCDS (TIDA) NS00732 (J T S ) and the Veterans Administration

PY - 1985

Y1 - 1985

N2 - Levels of monoamines and metabolites in rostral and caudal hypothalamic fragments of young (3-4 months) and old (25-26 months) Fischer 344-rats were compared. There were no differences between fragments of young animals. In senescent rats, 5-hydroxyindoleacetic acid (5HIAA) increased in both rostral and caudal hypothalamus. The ratio 5HIAA/5HT (serotonin), an index of serotonin turnover, increased only rostrally. This age-related increase of 5HIAA/5HT in rostral hypothalamus was associated with a decrease in [3H]-spiperone binding. There were no age-related changes of MAO-A activity in the hypothalamus or of serum tyrosine or tryptophan levels.

AB - Levels of monoamines and metabolites in rostral and caudal hypothalamic fragments of young (3-4 months) and old (25-26 months) Fischer 344-rats were compared. There were no differences between fragments of young animals. In senescent rats, 5-hydroxyindoleacetic acid (5HIAA) increased in both rostral and caudal hypothalamus. The ratio 5HIAA/5HT (serotonin), an index of serotonin turnover, increased only rostrally. This age-related increase of 5HIAA/5HT in rostral hypothalamus was associated with a decrease in [3H]-spiperone binding. There were no age-related changes of MAO-A activity in the hypothalamus or of serum tyrosine or tryptophan levels.

KW - Aging

KW - Hypothalamus

KW - MAO-A

KW - Serotonin

KW - [H]-Spiperone

UR - https://www.scopus.com/pages/publications/0022353561

UR - https://www.scopus.com/pages/publications/0022353561#tab=citedBy

U2 - 10.1016/0197-4580(85)90052-1

DO - 10.1016/0197-4580(85)90052-1

M3 - Article

C2 - 2414677

AN - SCOPUS:0022353561

SN - 0197-4580

VL - 6

SP - 213

EP - 217

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 3

ER -

Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this