Age-associated changes in ca2+-dependent processes: Relation to hippocampal synaptic plasticity

Thomas C. Foster, Christopher M. Norris

Research output: Contribution to journalArticlepeer-review

159 Scopus citations

Abstract

Altered calcium (Ca2+) homeostasis is thought to play a key role in aging and neuropathology resulting in memory deficits. Several forms of hippocampal synaptic plasticity are dependent on Ca2+, providing a potential link between altered Ca2+ homeostasis and memory deficits associated with aging. The current study reviews evidence for Ca2+ dysregulation during aging which could interact with Ca2+-dependent synaptic plasticity. The authors suggest that changes in Ca2+ regulation could adjust the thresholds for synaptic modification, favoring processes for depression of synaptic strength during aging.

Original languageEnglish
Pages (from-to)602-612
Number of pages11
JournalHippocampus
Volume7
Issue number6
DOIs
StatePublished - 1997

Keywords

  • Aging
  • Long-term depression
  • Long-term potentiation

ASJC Scopus subject areas

  • Cognitive Neuroscience

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