TY - JOUR
T1 - Age-associated changes in ca2+-dependent processes
T2 - Relation to hippocampal synaptic plasticity
AU - Foster, Thomas C.
AU - Norris, Christopher M.
PY - 1997
Y1 - 1997
N2 - Altered calcium (Ca2+) homeostasis is thought to play a key role in aging and neuropathology resulting in memory deficits. Several forms of hippocampal synaptic plasticity are dependent on Ca2+, providing a potential link between altered Ca2+ homeostasis and memory deficits associated with aging. The current study reviews evidence for Ca2+ dysregulation during aging which could interact with Ca2+-dependent synaptic plasticity. The authors suggest that changes in Ca2+ regulation could adjust the thresholds for synaptic modification, favoring processes for depression of synaptic strength during aging.
AB - Altered calcium (Ca2+) homeostasis is thought to play a key role in aging and neuropathology resulting in memory deficits. Several forms of hippocampal synaptic plasticity are dependent on Ca2+, providing a potential link between altered Ca2+ homeostasis and memory deficits associated with aging. The current study reviews evidence for Ca2+ dysregulation during aging which could interact with Ca2+-dependent synaptic plasticity. The authors suggest that changes in Ca2+ regulation could adjust the thresholds for synaptic modification, favoring processes for depression of synaptic strength during aging.
KW - Aging
KW - Long-term depression
KW - Long-term potentiation
UR - http://www.scopus.com/inward/record.url?scp=0031451847&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031451847&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1098-1063(1997)7:6<602::AID-HIPO3>3.0.CO;2-G
DO - 10.1002/(SICI)1098-1063(1997)7:6<602::AID-HIPO3>3.0.CO;2-G
M3 - Article
C2 - 9443057
AN - SCOPUS:0031451847
SN - 1050-9631
VL - 7
SP - 602
EP - 612
JO - Hippocampus
JF - Hippocampus
IS - 6
ER -