Age-associated changes of cerebrospinal fluid amyloid-β and tau incynomolgus monkeys

Feng Yue, Chunling Lu, Yi Ai, Piu Chan, Zhiming Zhang

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Nonhuman primates (NHPs) are useful for the study of age-associated changes in the brain as a model that is biologically closely related to humans. For example, with age, all NHPs analyzed to date, develop β-amyloid (Aβ) plaques as seen in humans. Nevertheless, it is still unclear if NHPs have human-like age-associated changes in Aβ and tau protein in cerebrospinal fluid. The present study was an attempt to specifically address these issues. Cerebrospinal fluid levels of Aβ and phosphorylated tau were measured in 37 and 22 cynomolgus monkeys, respectively, with ages ranging from 4 to 22-year-old. The result from the present study revealed significant age-associated declines in Aβ42 levels but not in Aβ40 and phosphorylated tau levels. This finding appears to parallel changes seen with human aging, in which decreased levels of Aβ42 can be seen in normal older adults, and supporting that cynomolgus monkeys would be a useful model for studying age-related neurologic disorders associated with Alzheimer-like cerebral proteopathy.

Original languageEnglish
Pages (from-to)1656-1659
Number of pages4
JournalNeurobiology of Aging
Volume35
Issue number7
DOIs
StatePublished - Jul 2014

Bibliographical note

Funding Information:
This study was supported by grants from the National Natural Science Foundation of China ( 31240043 ), State High-Tech Development Plan of Ministry of Sciences and Technology of China ( 2012AA020703 , 2012AA02A514 ), the National Basic Research Development Program of China ( 2011CB504101 ), and the Department of Anatomy and Neurobiology, University of Kentucky College of Medicine . The authors want to thank Dr Richard Grondin and Ms. April Evans for reviewing the manuscript.

Keywords

  • Age
  • CSF
  • Cynomolgus monkey
  • P-Tau
  • β-amyloid

ASJC Scopus subject areas

  • Neuroscience (all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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