Age-associated changes of cerebrospinal fluid amyloid-β and tau incynomolgus monkeys

Feng Yue; Chunling Lu; Yi Ai; Piu Chan; Zhiming Zhang

doi:10.1016/j.neurobiolaging.2014.01.139

Age-associated changes of cerebrospinal fluid amyloid-β and tau incynomolgus monkeys

Feng Yue, Chunling Lu, Yi Ai, Piu Chan, Zhiming Zhang

Neuroscience

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Nonhuman primates (NHPs) are useful for the study of age-associated changes in the brain as a model that is biologically closely related to humans. For example, with age, all NHPs analyzed to date, develop β-amyloid (Aβ) plaques as seen in humans. Nevertheless, it is still unclear if NHPs have human-like age-associated changes in Aβ and tau protein in cerebrospinal fluid. The present study was an attempt to specifically address these issues. Cerebrospinal fluid levels of Aβ and phosphorylated tau were measured in 37 and 22 cynomolgus monkeys, respectively, with ages ranging from 4 to 22-year-old. The result from the present study revealed significant age-associated declines in Aβ42 levels but not in Aβ40 and phosphorylated tau levels. This finding appears to parallel changes seen with human aging, in which decreased levels of Aβ42 can be seen in normal older adults, and supporting that cynomolgus monkeys would be a useful model for studying age-related neurologic disorders associated with Alzheimer-like cerebral proteopathy.

Original language	English
Pages (from-to)	1656-1659
Number of pages	4
Journal	Neurobiology of Aging
Volume	35
Issue number	7
DOIs	https://doi.org/10.1016/j.neurobiolaging.2014.01.139
State	Published - Jul 2014

Bibliographical note

Funding Information:
This study was supported by grants from the National Natural Science Foundation of China ( 31240043 ), State High-Tech Development Plan of Ministry of Sciences and Technology of China ( 2012AA020703 , 2012AA02A514 ), the National Basic Research Development Program of China ( 2011CB504101 ), and the Department of Anatomy and Neurobiology, University of Kentucky College of Medicine . The authors want to thank Dr Richard Grondin and Ms. April Evans for reviewing the manuscript.

Keywords

Age
CSF
Cynomolgus monkey
P-Tau
β-amyloid

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2014.01.139

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title = "Age-associated changes of cerebrospinal fluid amyloid-β and tau incynomolgus monkeys",

abstract = "Nonhuman primates (NHPs) are useful for the study of age-associated changes in the brain as a model that is biologically closely related to humans. For example, with age, all NHPs analyzed to date, develop β-amyloid (Aβ) plaques as seen in humans. Nevertheless, it is still unclear if NHPs have human-like age-associated changes in Aβ and tau protein in cerebrospinal fluid. The present study was an attempt to specifically address these issues. Cerebrospinal fluid levels of Aβ and phosphorylated tau were measured in 37 and 22 cynomolgus monkeys, respectively, with ages ranging from 4 to 22-year-old. The result from the present study revealed significant age-associated declines in Aβ42 levels but not in Aβ40 and phosphorylated tau levels. This finding appears to parallel changes seen with human aging, in which decreased levels of Aβ42 can be seen in normal older adults, and supporting that cynomolgus monkeys would be a useful model for studying age-related neurologic disorders associated with Alzheimer-like cerebral proteopathy.",

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author = "Feng Yue and Chunling Lu and Yi Ai and Piu Chan and Zhiming Zhang",

note = "Funding Information: This study was supported by grants from the National Natural Science Foundation of China ( 31240043 ), State High-Tech Development Plan of Ministry of Sciences and Technology of China ( 2012AA020703 , 2012AA02A514 ), the National Basic Research Development Program of China ( 2011CB504101 ), and the Department of Anatomy and Neurobiology, University of Kentucky College of Medicine . The authors want to thank Dr Richard Grondin and Ms. April Evans for reviewing the manuscript.",

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AU - Ai, Yi

AU - Chan, Piu

AU - Zhang, Zhiming

N1 - Funding Information: This study was supported by grants from the National Natural Science Foundation of China ( 31240043 ), State High-Tech Development Plan of Ministry of Sciences and Technology of China ( 2012AA020703 , 2012AA02A514 ), the National Basic Research Development Program of China ( 2011CB504101 ), and the Department of Anatomy and Neurobiology, University of Kentucky College of Medicine . The authors want to thank Dr Richard Grondin and Ms. April Evans for reviewing the manuscript.

PY - 2014/7

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N2 - Nonhuman primates (NHPs) are useful for the study of age-associated changes in the brain as a model that is biologically closely related to humans. For example, with age, all NHPs analyzed to date, develop β-amyloid (Aβ) plaques as seen in humans. Nevertheless, it is still unclear if NHPs have human-like age-associated changes in Aβ and tau protein in cerebrospinal fluid. The present study was an attempt to specifically address these issues. Cerebrospinal fluid levels of Aβ and phosphorylated tau were measured in 37 and 22 cynomolgus monkeys, respectively, with ages ranging from 4 to 22-year-old. The result from the present study revealed significant age-associated declines in Aβ42 levels but not in Aβ40 and phosphorylated tau levels. This finding appears to parallel changes seen with human aging, in which decreased levels of Aβ42 can be seen in normal older adults, and supporting that cynomolgus monkeys would be a useful model for studying age-related neurologic disorders associated with Alzheimer-like cerebral proteopathy.

AB - Nonhuman primates (NHPs) are useful for the study of age-associated changes in the brain as a model that is biologically closely related to humans. For example, with age, all NHPs analyzed to date, develop β-amyloid (Aβ) plaques as seen in humans. Nevertheless, it is still unclear if NHPs have human-like age-associated changes in Aβ and tau protein in cerebrospinal fluid. The present study was an attempt to specifically address these issues. Cerebrospinal fluid levels of Aβ and phosphorylated tau were measured in 37 and 22 cynomolgus monkeys, respectively, with ages ranging from 4 to 22-year-old. The result from the present study revealed significant age-associated declines in Aβ42 levels but not in Aβ40 and phosphorylated tau levels. This finding appears to parallel changes seen with human aging, in which decreased levels of Aβ42 can be seen in normal older adults, and supporting that cynomolgus monkeys would be a useful model for studying age-related neurologic disorders associated with Alzheimer-like cerebral proteopathy.

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Age-associated changes of cerebrospinal fluid amyloid-β and tau incynomolgus monkeys

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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