Age at menarche and risk of gestational diabetes mellitus: A prospective cohort study among 27,482 women

Liwei Chen, Shanshan Li, Chunyan He, Yeyi Zhu, Germaine M. Buck Louis, Edwina Yeung, Frank B. Hu, Cuilin Zhang

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Objective To examine the association between age at menarche and risk of gestational diabetes mellitus (GDM). Research Design and Methods A prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses' Health Study II. Results The adjusted risk ratios for GDM across the age at menarche categories (≤11, 12, 13, and ≥14 years) were 1.34 (95% CI 1.14-1.58), 1.13 (0.97-1.31), 1.11 (0.95- 1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1%(P = 0.0007) of the association wasmediated through prepregnancy BMI. Conclusions These findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.

Original languageEnglish
Pages (from-to)469-471
Number of pages3
JournalDiabetes Care
Volume39
Issue number3
DOIs
StatePublished - Mar 2016

Bibliographical note

Publisher Copyright:
© 2016 by the American Diabetes Association.

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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