Age at menarche and risk of gestational diabetes mellitus: A prospective cohort study among 27,482 women

Liwei Chen; Shanshan Li; Chunyan He; Yeyi Zhu; Germaine M. Buck Louis; Edwina Yeung; Frank B. Hu; Cuilin Zhang

doi:10.2337/dc15-2011

Age at menarche and risk of gestational diabetes mellitus: A prospective cohort study among 27,482 women

Liwei Chen, Shanshan Li, Chunyan He, Yeyi Zhu, Germaine M. Buck Louis, Edwina Yeung, Frank B. Hu, Cuilin Zhang

Internal Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Objective To examine the association between age at menarche and risk of gestational diabetes mellitus (GDM). Research Design and Methods A prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses' Health Study II. Results The adjusted risk ratios for GDM across the age at menarche categories (≤11, 12, 13, and ≥14 years) were 1.34 (95% CI 1.14-1.58), 1.13 (0.97-1.31), 1.11 (0.95- 1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1%(P = 0.0007) of the association wasmediated through prepregnancy BMI. Conclusions These findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.

Original language	English
Pages (from-to)	469-471
Number of pages	3
Journal	Diabetes Care
Volume	39
Issue number	3
DOIs	https://doi.org/10.2337/dc15-2011
State	Published - Mar 2016

Bibliographical note

Publisher Copyright:
© 2016 by the American Diabetes Association.

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Advanced and Specialized Nursing

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10.2337/dc15-2011

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abstract = "Objective To examine the association between age at menarche and risk of gestational diabetes mellitus (GDM). Research Design and Methods A prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses' Health Study II. Results The adjusted risk ratios for GDM across the age at menarche categories (≤11, 12, 13, and ≥14 years) were 1.34 (95% CI 1.14-1.58), 1.13 (0.97-1.31), 1.11 (0.95- 1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1%(P = 0.0007) of the association wasmediated through prepregnancy BMI. Conclusions These findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.",

author = "Liwei Chen and Shanshan Li and Chunyan He and Yeyi Zhu and {Buck Louis}, {Germaine M.} and Edwina Yeung and Hu, {Frank B.} and Cuilin Zhang",

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doi = "10.2337/dc15-2011",

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T2 - A prospective cohort study among 27,482 women

AU - Chen, Liwei

AU - Li, Shanshan

AU - He, Chunyan

AU - Zhu, Yeyi

AU - Buck Louis, Germaine M.

AU - Yeung, Edwina

AU - Hu, Frank B.

AU - Zhang, Cuilin

PY - 2016/3

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N2 - Objective To examine the association between age at menarche and risk of gestational diabetes mellitus (GDM). Research Design and Methods A prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses' Health Study II. Results The adjusted risk ratios for GDM across the age at menarche categories (≤11, 12, 13, and ≥14 years) were 1.34 (95% CI 1.14-1.58), 1.13 (0.97-1.31), 1.11 (0.95- 1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1%(P = 0.0007) of the association wasmediated through prepregnancy BMI. Conclusions These findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.

AB - Objective To examine the association between age at menarche and risk of gestational diabetes mellitus (GDM). Research Design and Methods A prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses' Health Study II. Results The adjusted risk ratios for GDM across the age at menarche categories (≤11, 12, 13, and ≥14 years) were 1.34 (95% CI 1.14-1.58), 1.13 (0.97-1.31), 1.11 (0.95- 1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1%(P = 0.0007) of the association wasmediated through prepregnancy BMI. Conclusions These findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.

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Age at menarche and risk of gestational diabetes mellitus: A prospective cohort study among 27,482 women

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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