Age-dependent changes in the ability to encode a novel elementary motor memory

Lumy Sawaki, Zaneb Yaseen, Leonid Kopylev, Leonardo G. Cohen

Research output: Contribution to journalArticlepeer-review

130 Scopus citations


In healthy individuals, motor training elicits cortical plasticity that encodes the kinematic details of the practiced movements and is thought to underlie recovery of function after stroke. The influence of age on this form of plasticity is incompletely understood. We studied 55 healthy subjects and identified a substantial decrease in training-dependent plasticity as a function of age in the absence of differences in training kinematics. These results suggest that the ability of the healthy aging motor cortex to reorganize in response to training decreases with age.

Original languageEnglish
Pages (from-to)521-524
Number of pages4
JournalAnnals of Neurology
Issue number4
StatePublished - Apr 1 2003

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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