Abstract
Rapid (5Hz) chronoamperometric recordings using Nafion-coated carbon fiber electrodes (30-90 microns o.d.) combined with pressure-ejection of potassium from micropipettes were used to investigate potassium-evoked overflow of dopamine (DA) in the striatum of young (5 to 10 years old) and middle-aged (19 to 23 years old) anesthetized rhesus monkeys. The potassium-evoked DA-like signals from the 19- to 23-year-old animals were significantly lower in amplitude than those recorded in the young animals. In addition, the temporal dynamics of DA signals in the caudate nucleus of middle-aged animals were faster, while the time courses of the signals recorded in the putamen of middle-aged monkeys were significantly longer as compared to the signals recorded from young animals. Moreover, home cage activity levels of the middle-aged animals were significantly lower. Taken together, these data support age-related changes in the output of DA from DA fibers in the striatum of middle-aged monkeys.
| Original language | English |
|---|---|
| Pages (from-to) | 939-946 |
| Number of pages | 8 |
| Journal | Neurobiology of Aging |
| Volume | 16 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1995 |
Bibliographical note
Funding Information:This work was supported by grants from USPHS NS-25778 to Don Gash, and NS-09199 and AG-06434 to Greg Gerhardt.
Keywords
- Caudate nucleus
- Nigrostriatal dopamine pathway
- Nonhuman primates
- Parkinson's disease
- Putamen
ASJC Scopus subject areas
- General Neuroscience
- Aging
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology