Age-related changes in potassium-evoked overflow of dopamine in the striatum of the rhesus monkey

Greg A. Gerhardt, Wayne A. Cass, Michael Henson, Zhiming Zhang, Aliza Ovadia, Barry J. Hoffer, Don M. Gash

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Rapid (5Hz) chronoamperometric recordings using Nafion-coated carbon fiber electrodes (30-90 microns o.d.) combined with pressure-ejection of potassium from micropipettes were used to investigate potassium-evoked overflow of dopamine (DA) in the striatum of young (5 to 10 years old) and middle-aged (19 to 23 years old) anesthetized rhesus monkeys. The potassium-evoked DA-like signals from the 19- to 23-year-old animals were significantly lower in amplitude than those recorded in the young animals. In addition, the temporal dynamics of DA signals in the caudate nucleus of middle-aged animals were faster, while the time courses of the signals recorded in the putamen of middle-aged monkeys were significantly longer as compared to the signals recorded from young animals. Moreover, home cage activity levels of the middle-aged animals were significantly lower. Taken together, these data support age-related changes in the output of DA from DA fibers in the striatum of middle-aged monkeys.

Original languageEnglish
Pages (from-to)939-946
Number of pages8
JournalNeurobiology of Aging
Volume16
Issue number6
DOIs
StatePublished - 1995

Bibliographical note

Funding Information:
This work was supported by grants from USPHS NS-25778 to Don Gash, and NS-09199 and AG-06434 to Greg Gerhardt.

Keywords

  • Caudate nucleus
  • Nigrostriatal dopamine pathway
  • Nonhuman primates
  • Parkinson's disease
  • Putamen

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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