Age-related changes in serum and brain levels of androgens in male Brown Norway rats

Emily R. Rosario, Lilly Chang, Tina L. Beckett, Jenna C. Carroll, M. Paul Murphy, Frank Z. Stanczyk, Christian J. Pike

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum levels of androgens and estrogen in aging male rats. We observed that increasing age was associated with a significant reduction in brain levels of the potent androgen dihydrotestosterone and a trend toward decreased testosterone. Brain levels of soluble β-amyloid were observed to increase with age. Collectively, these findings highlight differences in brain and circulating levels of androgens during aging, and identify an inverse correlation with β-amyloid levels that may be relevant to Alzheimer's disease risk.

Original languageEnglish
Pages (from-to)1534-1537
Number of pages4
Issue number17
StatePublished - Nov 25 2009


  • Aging
  • Alzheimer's disease
  • B-amyloid
  • Dihydrotestosterone
  • Estrogen
  • Testosterone

ASJC Scopus subject areas

  • General Neuroscience


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