Age-related changes in serum and brain levels of androgens in male Brown Norway rats

Emily R. Rosario; Lilly Chang; Tina L. Beckett; Jenna C. Carroll; M. Paul Murphy; Frank Z. Stanczyk; Christian J. Pike

doi:10.1097/WNR.0b013e328331f968

Age-related changes in serum and brain levels of androgens in male Brown Norway rats

Emily R. Rosario, Lilly Chang, Tina L. Beckett, Jenna C. Carroll, M. Paul Murphy, Frank Z. Stanczyk, Christian J. Pike

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum levels of androgens and estrogen in aging male rats. We observed that increasing age was associated with a significant reduction in brain levels of the potent androgen dihydrotestosterone and a trend toward decreased testosterone. Brain levels of soluble β-amyloid were observed to increase with age. Collectively, these findings highlight differences in brain and circulating levels of androgens during aging, and identify an inverse correlation with β-amyloid levels that may be relevant to Alzheimer's disease risk.

Original language	English
Pages (from-to)	1534-1537
Number of pages	4
Journal	NeuroReport
Volume	20
Issue number	17
DOIs	https://doi.org/10.1097/WNR.0b013e328331f968
State	Published - Nov 25 2009

Keywords

Aging
Alzheimer's disease
B-amyloid
Dihydrotestosterone
Estrogen
Testosterone

ASJC Scopus subject areas

General Neuroscience

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10.1097/WNR.0b013e328331f968

Cite this

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title = "Age-related changes in serum and brain levels of androgens in male Brown Norway rats",

abstract = "Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum levels of androgens and estrogen in aging male rats. We observed that increasing age was associated with a significant reduction in brain levels of the potent androgen dihydrotestosterone and a trend toward decreased testosterone. Brain levels of soluble β-amyloid were observed to increase with age. Collectively, these findings highlight differences in brain and circulating levels of androgens during aging, and identify an inverse correlation with β-amyloid levels that may be relevant to Alzheimer's disease risk.",

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AU - Rosario, Emily R.

AU - Chang, Lilly

AU - Beckett, Tina L.

AU - Carroll, Jenna C.

AU - Paul Murphy, M.

AU - Stanczyk, Frank Z.

AU - Pike, Christian J.

PY - 2009/11/25

Y1 - 2009/11/25

N2 - Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum levels of androgens and estrogen in aging male rats. We observed that increasing age was associated with a significant reduction in brain levels of the potent androgen dihydrotestosterone and a trend toward decreased testosterone. Brain levels of soluble β-amyloid were observed to increase with age. Collectively, these findings highlight differences in brain and circulating levels of androgens during aging, and identify an inverse correlation with β-amyloid levels that may be relevant to Alzheimer's disease risk.

AB - Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum levels of androgens and estrogen in aging male rats. We observed that increasing age was associated with a significant reduction in brain levels of the potent androgen dihydrotestosterone and a trend toward decreased testosterone. Brain levels of soluble β-amyloid were observed to increase with age. Collectively, these findings highlight differences in brain and circulating levels of androgens during aging, and identify an inverse correlation with β-amyloid levels that may be relevant to Alzheimer's disease risk.

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KW - Alzheimer's disease

KW - B-amyloid

KW - Dihydrotestosterone

KW - Estrogen

KW - Testosterone

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Age-related changes in serum and brain levels of androgens in male Brown Norway rats

Abstract

Keywords

ASJC Scopus subject areas

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