@article{f88012914cba4eb18eb2b373acb4fab2,
title = "Age-related changes in serum and brain levels of androgens in male Brown Norway rats",
abstract = "Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum levels of androgens and estrogen in aging male rats. We observed that increasing age was associated with a significant reduction in brain levels of the potent androgen dihydrotestosterone and a trend toward decreased testosterone. Brain levels of soluble β-amyloid were observed to increase with age. Collectively, these findings highlight differences in brain and circulating levels of androgens during aging, and identify an inverse correlation with β-amyloid levels that may be relevant to Alzheimer's disease risk.",
keywords = "Aging, Alzheimer's disease, B-amyloid, Dihydrotestosterone, Estrogen, Testosterone",
author = "Rosario, \{Emily R.\} and Lilly Chang and Beckett, \{Tina L.\} and Carroll, \{Jenna C.\} and \{Paul Murphy\}, M. and Stanczyk, \{Frank Z.\} and Pike, \{Christian J.\}",
year = "2009",
month = nov,
day = "25",
doi = "10.1097/WNR.0b013e328331f968",
language = "English",
volume = "20",
pages = "1534--1537",
number = "17",
}