Age-related losses in cardiac autonomic activity during a daytime nap

Pin Chun Chen, Negin Sattari, Lauren N. Whitehurst, Sara C. Mednick

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

In healthy, young individuals, a reduction in cardiovascular output and a shift from sympathetic to parasympathetic (vagal) dominance is observed from wake into stages of nocturnal and daytime sleep. This cardiac autonomic profile, measured by heart rate variability (HRV), has been associated with significant benefits for cardiovascular health. Aging is associated with decreased nighttime sleep quality and lower parasympathetic activity during both sleep and resting. However, it is not known whether age-related dampening of HRV extends to daytime sleep, diminishing the cardiovascular benefits of naps in the elderly. Here, we investigated this question by comparing the autonomic activity profile between young and older healthy adults during a daytime nap and a similar period of wakefulness (quiet wake; QW). For each condition, from the electrocardiogram (ECG), we obtained beat-to-beat HRV intervals (RR), root mean square of successive differences between adjacent heart-beat-intervals (RMSSD), high-frequency (HF), low-frequency (LF) power, and total power (TP), HF normalized units (HFnu), and the LF/HF ratio. As previously reported, young subjects showed a parasympathetic dominance during NREM, compared with REM, prenap rest, and WASO. Moreover, older, compared to younger, adults showed significantly lower vagally mediated HRV (measured by RMSSD, HF, HFnu) during NREM. Interestingly, however, no age-related differences were detected during prenap rest or QW. Altogether, our findings suggest a sleep-specific reduction in parasympathetic modulation that is unique to NREM sleep in older adults.

Original languageEnglish
Article numbere13701
JournalPsychophysiology
Volume58
Issue number7
DOIs
StatePublished - Jul 2021

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health R01 (AG046646) and (AG061355). P.C. analyzed data and wrote the paper; S.C.M, L.N.W., and N.S. designed the study; L.N.W. and N.S. performed research; and S.C.M. supervised research. S.C.M, L.N.W., and N.S. edited the paper.

Publisher Copyright:
© 2020 The Authors. Psychophysiology published by Wiley Periodicals LLC on behalf of Society for Psychophysiological Research

Keywords

  • aging
  • autonomic activity
  • heart rate variability
  • nap
  • sleep

ASJC Scopus subject areas

  • Neuroscience (all)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Neurology
  • Endocrine and Autonomic Systems
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Biological Psychiatry

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