Age-specific onset of β-amyloid in beagle brains

Michael J. Russell, Marketta Bobik, Russell G. White, Yongjin Hou, Stephen A. Benjamin, James W. Geddes

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


As part of an effort to characterize Alzheimer's disease-like neuropathy in the canine brain we have determined the age of onset of spontaneous β-amyloid deposition in 103 laboratory-raised beagles. Tissue samples for each subject were obtained from hippocampal and cortical regions and examined for the incidence and density of β-amyloid deposition after staining with modified Bielschowsky silver stain and immunohistochemistry. Amyloid deposition was characterized as diffuse plaque or cloud-like formation. The diffuse type of β-amyloid plaque formation predominated in all brain regions examined. A threshold effect of plaque development was observed; no plaques were apparent in dogs before the age of 10 years, while 36% of dogs aged 11.1-12.9, 60% of dogs aged 13.0-15.0, and 73% of dogs aged 15.1-17.8 developed P-amyloid deposits. Additionally, a significant increase in plaque density was observed with increasing age.

Original languageEnglish
Pages (from-to)269-273
Number of pages5
JournalNeurobiology of Aging
Issue number2
StatePublished - 1996

Bibliographical note

Funding Information:
We thank Athena Neurosciences (South San Francisco, CA) for their generous donation of the antibody 10D5 for this project. The study was supported by NIH Grants AG11350, AG10678, the Alzheimer's Disease Association, and the Food and Drug Administration FDA 223-92-6001 from the Center for Devices and Radiological Health.

ASJC Scopus subject areas

  • Neuroscience (all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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