Age-specific onset of β-amyloid in beagle brains

Michael J. Russell; Marketta Bobik; Russell G. White; Yongjin Hou; Stephen A. Benjamin; James W. Geddes

doi:10.1016/0197-4580(95)02072-1

Age-specific onset of β-amyloid in beagle brains

Michael J. Russell, Marketta Bobik, Russell G. White, Yongjin Hou, Stephen A. Benjamin, James W. Geddes

Neuroscience

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

As part of an effort to characterize Alzheimer's disease-like neuropathy in the canine brain we have determined the age of onset of spontaneous β-amyloid deposition in 103 laboratory-raised beagles. Tissue samples for each subject were obtained from hippocampal and cortical regions and examined for the incidence and density of β-amyloid deposition after staining with modified Bielschowsky silver stain and immunohistochemistry. Amyloid deposition was characterized as diffuse plaque or cloud-like formation. The diffuse type of β-amyloid plaque formation predominated in all brain regions examined. A threshold effect of plaque development was observed; no plaques were apparent in dogs before the age of 10 years, while 36% of dogs aged 11.1-12.9, 60% of dogs aged 13.0-15.0, and 73% of dogs aged 15.1-17.8 developed P-amyloid deposits. Additionally, a significant increase in plaque density was observed with increasing age.

Original language	English
Pages (from-to)	269-273
Number of pages	5
Journal	Neurobiology of Aging
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/0197-4580(95)02072-1
State	Published - 1996

Bibliographical note

Funding Information:
We thank Athena Neurosciences (South San Francisco, CA) for their generous donation of the antibody 10D5 for this project. The study was supported by NIH Grants AG11350, AG10678, the Alzheimer's Disease Association, and the Food and Drug Administration FDA 223-92-6001 from the Center for Devices and Radiological Health.

Funding

We thank Athena Neurosciences (South San Francisco, CA) for their generous donation of the antibody 10D5 for this project. The study was supported by NIH Grants AG11350, AG10678, the Alzheimer's Disease Association, and the Food and Drug Administration FDA 223-92-6001 from the Center for Devices and Radiological Health.

Funders	Funder number
National Institutes of Health (NIH)	AG11350
U.S. Food and Drug Administration	FDA 223-92-6001
National Institute on Aging	R01AG010678
Alzheimer's Association

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/0197-4580(95)02072-1

Cite this

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title = "Age-specific onset of β-amyloid in beagle brains",

abstract = "As part of an effort to characterize Alzheimer's disease-like neuropathy in the canine brain we have determined the age of onset of spontaneous β-amyloid deposition in 103 laboratory-raised beagles. Tissue samples for each subject were obtained from hippocampal and cortical regions and examined for the incidence and density of β-amyloid deposition after staining with modified Bielschowsky silver stain and immunohistochemistry. Amyloid deposition was characterized as diffuse plaque or cloud-like formation. The diffuse type of β-amyloid plaque formation predominated in all brain regions examined. A threshold effect of plaque development was observed; no plaques were apparent in dogs before the age of 10 years, while 36% of dogs aged 11.1-12.9, 60% of dogs aged 13.0-15.0, and 73% of dogs aged 15.1-17.8 developed P-amyloid deposits. Additionally, a significant increase in plaque density was observed with increasing age.",

author = "Russell, {Michael J.} and Marketta Bobik and White, {Russell G.} and Yongjin Hou and Benjamin, {Stephen A.} and Geddes, {James W.}",

note = "Funding Information: We thank Athena Neurosciences (South San Francisco, CA) for their generous donation of the antibody 10D5 for this project. The study was supported by NIH Grants AG11350, AG10678, the Alzheimer's Disease Association, and the Food and Drug Administration FDA 223-92-6001 from the Center for Devices and Radiological Health.",

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AU - Bobik, Marketta

AU - White, Russell G.

AU - Hou, Yongjin

AU - Benjamin, Stephen A.

AU - Geddes, James W.

N1 - Funding Information: We thank Athena Neurosciences (South San Francisco, CA) for their generous donation of the antibody 10D5 for this project. The study was supported by NIH Grants AG11350, AG10678, the Alzheimer's Disease Association, and the Food and Drug Administration FDA 223-92-6001 from the Center for Devices and Radiological Health.

PY - 1996

Y1 - 1996

N2 - As part of an effort to characterize Alzheimer's disease-like neuropathy in the canine brain we have determined the age of onset of spontaneous β-amyloid deposition in 103 laboratory-raised beagles. Tissue samples for each subject were obtained from hippocampal and cortical regions and examined for the incidence and density of β-amyloid deposition after staining with modified Bielschowsky silver stain and immunohistochemistry. Amyloid deposition was characterized as diffuse plaque or cloud-like formation. The diffuse type of β-amyloid plaque formation predominated in all brain regions examined. A threshold effect of plaque development was observed; no plaques were apparent in dogs before the age of 10 years, while 36% of dogs aged 11.1-12.9, 60% of dogs aged 13.0-15.0, and 73% of dogs aged 15.1-17.8 developed P-amyloid deposits. Additionally, a significant increase in plaque density was observed with increasing age.

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Age-specific onset of β-amyloid in beagle brains

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

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