Aged F344 rats exhibit altered electrophysiological activity in locomotor-unrelated but not locomotor-related striatal neurons

John A. Stanford; Greg A. Gerhardt

doi:10.1016/S0197-4580(03)00128-3

Aged F344 rats exhibit altered electrophysiological activity in locomotor-unrelated but not locomotor-related striatal neurons

John A. Stanford, Greg A. Gerhardt

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Multi-wire electrode arrays were chronically implanted and striatal electrophysiological activity was recorded in young (4-9 months) versus aged (24-29 months) Fischer 344 (F344) rats in order to determine whether locomotor-related striatal neurons exhibit age-related changes in electrophysiological activity during freely-moving conditions. Individual neurons were classified as locomotor-related if they exhibited significant differences in their firing rates between periods of locomotion versus periods of non-movement. While the activity of locomotor-related striatal neurons did not differ between young and aged rats, neurons that were not related to locomotion exhibited significantly greater activity in the aged rats during both periods of non-movement and bouts of locomotion. These results suggest that in the aged striatum, increased activity of nonlocomotor-related neurons may contribute to hypokinesia through their influence on basal ganglia output nuclei. Such studies may aid in the understanding of movement disorders seen in aging and Parkinson's disease.

Original language	English
Pages (from-to)	509-515
Number of pages	7
Journal	Neurobiology of Aging
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/S0197-4580(03)00128-3
State	Published - Apr 2004

Bibliographical note

Funding Information:
The authors thank Jeremy P. Stich, Clelland R. Gash and Theresa D. Currier for their assistance in this study. This work was supported by grants from USPHS AG06434, AG13494, NS39787, and a level II Research Scientist Award (MH01245) to G. Gerhardt.

Funding

The authors thank Jeremy P. Stich, Clelland R. Gash and Theresa D. Currier for their assistance in this study. This work was supported by grants from USPHS AG06434, AG13494, NS39787, and a level II Research Scientist Award (MH01245) to G. Gerhardt.

Funders	Funder number
National Institute on Aging	R29AG006434
U.S. Public Health Service	AG13494, AG06434, NS39787, MH01245

Keywords

Aging
Awake
Basal ganglia
Behaving
Dopamine
Electrophysiology
Freely-moving
Multiunit
Striatum

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/S0197-4580(03)00128-3

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title = "Aged F344 rats exhibit altered electrophysiological activity in locomotor-unrelated but not locomotor-related striatal neurons",

abstract = "Multi-wire electrode arrays were chronically implanted and striatal electrophysiological activity was recorded in young (4-9 months) versus aged (24-29 months) Fischer 344 (F344) rats in order to determine whether locomotor-related striatal neurons exhibit age-related changes in electrophysiological activity during freely-moving conditions. Individual neurons were classified as locomotor-related if they exhibited significant differences in their firing rates between periods of locomotion versus periods of non-movement. While the activity of locomotor-related striatal neurons did not differ between young and aged rats, neurons that were not related to locomotion exhibited significantly greater activity in the aged rats during both periods of non-movement and bouts of locomotion. These results suggest that in the aged striatum, increased activity of nonlocomotor-related neurons may contribute to hypokinesia through their influence on basal ganglia output nuclei. Such studies may aid in the understanding of movement disorders seen in aging and Parkinson's disease.",

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note = "Funding Information: The authors thank Jeremy P. Stich, Clelland R. Gash and Theresa D. Currier for their assistance in this study. This work was supported by grants from USPHS AG06434, AG13494, NS39787, and a level II Research Scientist Award (MH01245) to G. Gerhardt.",

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N2 - Multi-wire electrode arrays were chronically implanted and striatal electrophysiological activity was recorded in young (4-9 months) versus aged (24-29 months) Fischer 344 (F344) rats in order to determine whether locomotor-related striatal neurons exhibit age-related changes in electrophysiological activity during freely-moving conditions. Individual neurons were classified as locomotor-related if they exhibited significant differences in their firing rates between periods of locomotion versus periods of non-movement. While the activity of locomotor-related striatal neurons did not differ between young and aged rats, neurons that were not related to locomotion exhibited significantly greater activity in the aged rats during both periods of non-movement and bouts of locomotion. These results suggest that in the aged striatum, increased activity of nonlocomotor-related neurons may contribute to hypokinesia through their influence on basal ganglia output nuclei. Such studies may aid in the understanding of movement disorders seen in aging and Parkinson's disease.

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Aged F344 rats exhibit altered electrophysiological activity in locomotor-unrelated but not locomotor-related striatal neurons

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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