Aging enhances the neuroinflammatory response and α-synuclein nitration in rats

Dong Young Choi, Jinlu Zhang, Guoying Bing

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The Lewy body is a pathological hallmark of Parkinson's disease. It has been revealed that the Lewy body contains nitrated α-synuclein which is prone to oligomerization. We tested the hypothesis that aging may enhance nitration of α-synuclein due to an exaggerated neuroinflammatory reaction such as an excessive induction of the inducible nitric oxide synthase, which occurs post-intrapallidal lipopolysaccharide (LPS) injection. Here, we show microglia activation and proinflammatory cytokine expression are more evident in the substantia nigra of elderly rats following intrapallidal LPS. In addition, greater nitration of proteins like α-synuclein occurs in the substantia nigra of 16-month-old rats versus 3-month-old rats, which is accompanied by a higher expression level of inducible nitric oxide synthase. These results imply that an exaggerated neuroinflammatory response that occurs with aging might be involved in the increase in prevalence of neurodegenerative diseases like Parkinson's disease.

Original languageEnglish
Pages (from-to)1649-1653
Number of pages5
JournalNeurobiology of Aging
Volume31
Issue number9
DOIs
StatePublished - Sep 2010

Keywords

  • Aging
  • INOS
  • Microglia
  • Nitration
  • Parkinson's disease
  • α-Synuclein

ASJC Scopus subject areas

  • Neuroscience (all)
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology

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