Airway extravasation induced by increasing airway temperature in ovalbumin-sensitized rats

Chun Chun Hsu, Reyno J. Tapia, Lu Yuan Lee

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

This study was carried out to determine whether hyperventilation of humidified warm air (HWA) induced airway extravasation in ovalbumin (Ova)-sensitized rats. Our results showed: (1) After isocapnic hyperventilation with HWA for 2min, tracheal temperature (Ttr) was increased to 40.3°C, and the Evans blue contents in major airways and lung tissue were elevated to 651% and 707%, respectively, of that after hyperventilation with humidified room air in Ova-sensitized rats; this striking effect of HWA was absent in control rats. (2) The HWA-induced increase in Evans blue content in sensitized rats was completely prevented by a pretreatment with either L-732138, a selective antagonist of neurokinin type 1 (NK-1) receptor, or formoterol, a selective agonist of β2 adrenoceptor. This study demonstrated that an increase in airway temperature induced protein extravasation in the major airways and lung tissue of sensitized rats, and an activation of the NK-1 receptor by tachykinins released from bronchopulmonary C-fiber nerve endings was primarily responsible.

Original languageEnglish
Pages (from-to)46-49
Number of pages4
JournalRespiratory Physiology and Neurobiology
Volume212-214
DOIs
StatePublished - Jul 1 2015

Bibliographical note

Publisher Copyright:
© 2015.

Funding

This study was supported in part by US Department of Defense DMRDP/USAMRMC/TATRC Award W81XWH-10-2-0189 , NIH National Heart, Lung and Blood Institute grant HL-96914 and National Center for Advancing Translational Sciences grant UL1TR0000117 .

FundersFunder number
U.S. Department of DefenseW81XWH-10-2-0189
National Heart, Lung, and Blood Institute (NHLBI)R01HL096914
National Center for Advancing Translational Sciences (NCATS)UL1TR0000117

    Keywords

    • Asthma
    • Bronchoconstriction
    • C-fiber
    • Tachykinins
    • Vagus

    ASJC Scopus subject areas

    • General Neuroscience
    • Physiology
    • Pulmonary and Respiratory Medicine

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