Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women

B. C.H. Chiu; J. R. Cerhan; S. M. Gapstur; T. A. Sellers; W. Zheng; C. T. Lutz; R. B. Wallace; J. D. Potter

doi:10.1038/sj.bjc.6690547

Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women

B. C.H. Chiu, J. R. Cerhan, S. M. Gapstur, T. A. Sellers, W. Zheng, C. T. Lutz, R. B. Wallace, J. D. Potter

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

We investigated the relation of alcohol consumption to risk of non-Hodgkin's lymphoma (NHL) in a cohort of 36,156 Iowa women aged 55-69 years who participated in the Iowa Women's Health Study in 1986. Alcohol consumption at baseline was obtained using a mailed questionnaire. During the 9-year follow-up period, 143 incident cases of NHL were identified. Higher alcohol consumption was significantly associated with a decreased risk of NHL (P-trend = 0.03). Compared to non-drinkers, multivariate-adjusted relative risks (RRs) were decreased for women with intake of ≤ 3.4 g day^-1 (RR = 0.78; 95% confidence interval (CI 0.51-1.21) and > 3.4 g day^-1 (RR = 0.59; 0.36-0.97). The inverse association could not be attributed to one particular type of alcoholic beverage, although red wine (RR = 0.21 for > 2 glasses per month vs non-drinker, 0.05-0.86; P-trend = 0.02) has the most distinct effect. The apparent protective effect was universal regardless of specific NHL grade or Working Formulation subtype, but was most pronounced for nodal NHL (RR = 0.48; 0.26-0.90; P-trend = 0.01) and low-grade NHL (RR = 0.52: 0.21-1.26; P-trend = 0.05). These data suggest that moderate alcohol consumption is inversely associated with the risk of NHL in older women and the amount of alcohol consumed, rather than the type of alcoholic beverages, appears to be the main effect determinant.

Original language	English
Pages (from-to)	1476-1482
Number of pages	7
Journal	British Journal of Cancer
Volume	80
Issue number	9
DOIs	https://doi.org/10.1038/sj.bjc.6690547
State	Published - 1999

Bibliographical note

Funding Information:
The authors thank Kathleen McKeen, State Health Registry of Iowa, and Ching-Ping Hong, MS, University of Minnesota, for their helpful contributions. This research was supported by National Cancer Institute Grant R01 CA39742. Dr Cerhan was supported in part by a National Cancer Institute Preventive Oncology Academic Award (K07 CA64220).

Keywords

Alcohol
Cohort study
Lymphoma
Non-Hodgkin

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/sj.bjc.6690547

Cite this

@article{5a760661dcd14971916690340aa23766,

title = "Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women",

abstract = "We investigated the relation of alcohol consumption to risk of non-Hodgkin's lymphoma (NHL) in a cohort of 36,156 Iowa women aged 55-69 years who participated in the Iowa Women's Health Study in 1986. Alcohol consumption at baseline was obtained using a mailed questionnaire. During the 9-year follow-up period, 143 incident cases of NHL were identified. Higher alcohol consumption was significantly associated with a decreased risk of NHL (P-trend = 0.03). Compared to non-drinkers, multivariate-adjusted relative risks (RRs) were decreased for women with intake of ≤ 3.4 g day-1 (RR = 0.78; 95% confidence interval (CI 0.51-1.21) and > 3.4 g day-1 (RR = 0.59; 0.36-0.97). The inverse association could not be attributed to one particular type of alcoholic beverage, although red wine (RR = 0.21 for > 2 glasses per month vs non-drinker, 0.05-0.86; P-trend = 0.02) has the most distinct effect. The apparent protective effect was universal regardless of specific NHL grade or Working Formulation subtype, but was most pronounced for nodal NHL (RR = 0.48; 0.26-0.90; P-trend = 0.01) and low-grade NHL (RR = 0.52: 0.21-1.26; P-trend = 0.05). These data suggest that moderate alcohol consumption is inversely associated with the risk of NHL in older women and the amount of alcohol consumed, rather than the type of alcoholic beverages, appears to be the main effect determinant.",

keywords = "Alcohol, Cohort study, Lymphoma, Non-Hodgkin",

author = "Chiu, {B. C.H.} and Cerhan, {J. R.} and Gapstur, {S. M.} and Sellers, {T. A.} and W. Zheng and Lutz, {C. T.} and Wallace, {R. B.} and Potter, {J. D.}",

note = "Funding Information: The authors thank Kathleen McKeen, State Health Registry of Iowa, and Ching-Ping Hong, MS, University of Minnesota, for their helpful contributions. This research was supported by National Cancer Institute Grant R01 CA39742. Dr Cerhan was supported in part by a National Cancer Institute Preventive Oncology Academic Award (K07 CA64220).",

year = "1999",

doi = "10.1038/sj.bjc.6690547",

language = "English",

volume = "80",

pages = "1476--1482",

number = "9",

}

TY - JOUR

T1 - Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women

AU - Chiu, B. C.H.

AU - Cerhan, J. R.

AU - Gapstur, S. M.

AU - Sellers, T. A.

AU - Zheng, W.

AU - Lutz, C. T.

AU - Wallace, R. B.

AU - Potter, J. D.

N1 - Funding Information: The authors thank Kathleen McKeen, State Health Registry of Iowa, and Ching-Ping Hong, MS, University of Minnesota, for their helpful contributions. This research was supported by National Cancer Institute Grant R01 CA39742. Dr Cerhan was supported in part by a National Cancer Institute Preventive Oncology Academic Award (K07 CA64220).

PY - 1999

Y1 - 1999

N2 - We investigated the relation of alcohol consumption to risk of non-Hodgkin's lymphoma (NHL) in a cohort of 36,156 Iowa women aged 55-69 years who participated in the Iowa Women's Health Study in 1986. Alcohol consumption at baseline was obtained using a mailed questionnaire. During the 9-year follow-up period, 143 incident cases of NHL were identified. Higher alcohol consumption was significantly associated with a decreased risk of NHL (P-trend = 0.03). Compared to non-drinkers, multivariate-adjusted relative risks (RRs) were decreased for women with intake of ≤ 3.4 g day-1 (RR = 0.78; 95% confidence interval (CI 0.51-1.21) and > 3.4 g day-1 (RR = 0.59; 0.36-0.97). The inverse association could not be attributed to one particular type of alcoholic beverage, although red wine (RR = 0.21 for > 2 glasses per month vs non-drinker, 0.05-0.86; P-trend = 0.02) has the most distinct effect. The apparent protective effect was universal regardless of specific NHL grade or Working Formulation subtype, but was most pronounced for nodal NHL (RR = 0.48; 0.26-0.90; P-trend = 0.01) and low-grade NHL (RR = 0.52: 0.21-1.26; P-trend = 0.05). These data suggest that moderate alcohol consumption is inversely associated with the risk of NHL in older women and the amount of alcohol consumed, rather than the type of alcoholic beverages, appears to be the main effect determinant.

AB - We investigated the relation of alcohol consumption to risk of non-Hodgkin's lymphoma (NHL) in a cohort of 36,156 Iowa women aged 55-69 years who participated in the Iowa Women's Health Study in 1986. Alcohol consumption at baseline was obtained using a mailed questionnaire. During the 9-year follow-up period, 143 incident cases of NHL were identified. Higher alcohol consumption was significantly associated with a decreased risk of NHL (P-trend = 0.03). Compared to non-drinkers, multivariate-adjusted relative risks (RRs) were decreased for women with intake of ≤ 3.4 g day-1 (RR = 0.78; 95% confidence interval (CI 0.51-1.21) and > 3.4 g day-1 (RR = 0.59; 0.36-0.97). The inverse association could not be attributed to one particular type of alcoholic beverage, although red wine (RR = 0.21 for > 2 glasses per month vs non-drinker, 0.05-0.86; P-trend = 0.02) has the most distinct effect. The apparent protective effect was universal regardless of specific NHL grade or Working Formulation subtype, but was most pronounced for nodal NHL (RR = 0.48; 0.26-0.90; P-trend = 0.01) and low-grade NHL (RR = 0.52: 0.21-1.26; P-trend = 0.05). These data suggest that moderate alcohol consumption is inversely associated with the risk of NHL in older women and the amount of alcohol consumed, rather than the type of alcoholic beverages, appears to be the main effect determinant.

KW - Alcohol

KW - Cohort study

KW - Lymphoma

KW - Non-Hodgkin

UR - http://www.scopus.com/inward/record.url?scp=0033058640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033058640&partnerID=8YFLogxK

U2 - 10.1038/sj.bjc.6690547

DO - 10.1038/sj.bjc.6690547

M3 - Article

C2 - 10424754

AN - SCOPUS:0033058640

SN - 0007-0920

VL - 80

SP - 1476

EP - 1482

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 9

ER -

Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this