Abstract
Excessive alcohol intake, a hallmark of an alcohol use disorder (AUD), results in significant behavioral and cognitive impairments due to neuroplastic and neurotoxic changes in both central nervous system structure and function. Alcohol not only directly induces neurotoxicity through cell death, but its impact on constitutive adult neurogenesis via neural stem and progenitor cells may also contribute to neurodegeneration via lack of cell generation in some brain regions. It is unlikely mere coincidence that alcohol impairment of brain structure and function parallels the effect of alcohol on neural stem cells and adult neurogenesis during alcohol intoxication versus recovery in abstinence. In this chapter, we provide an overview of the important highlights in the seminal discoveries of neural stem cells and neurogenesis in the adult brain and then discuss the effects of alcohol on the various components of adult neurogenesis.
| Original language | English |
|---|---|
| Title of host publication | Stem Cells in Birth Defects Research and Developmental Toxicology |
| Pages | 173-222 |
| Number of pages | 50 |
| ISBN (Electronic) | 9781119283249 |
| DOIs | |
| State | Published - May 18 2018 |
Bibliographical note
Publisher Copyright:© 2018 John Wiley & Sons, Inc.
Keywords
- Adult neurogenesis
- Alcoholism
- Ethanol
- Neural stem cell
- Neurodegeneration
ASJC Scopus subject areas
- General Chemistry
- General Pharmacology, Toxicology and Pharmaceutics
- General Biochemistry, Genetics and Molecular Biology
