TY - JOUR
T1 - Alcohol-Induced Neurodegeneration
T2 - When, Where and Why?
AU - Crews, Fulton T.
AU - Collins, Michael A.
AU - Dlugos, Cynthia
AU - Littleton, John
AU - Wilkins, Lincoln
AU - Neafsey, Edward J.
AU - Pentney, Roberta
AU - Snell, Lawrence D.
AU - Tabakoff, Boris
AU - Zou, Jian
AU - Noronha, Antonio
PY - 2004/2
Y1 - 2004/2
N2 - This manuscript reviews the proceedings of a symposium organized by Drs. Antonio Noronha and Fulton Crews presented at the 2003 Research Society on Alcoholism meeting. The purpose of the symposium was to examine recent findings on when alcohol induced brain damage occurs, e.g., during intoxication and/or during alcohol withdrawal. Further studies investigate specific brain regions (where) and the mechanisms (why) of alcoholic neurodegeneration. The presentations were (1) Characterization of Synaptic Loss in Cerebella of Mature and Senescent Rats after Lengthy Chronic Ethanol Consumption, (2) Ethanol Withdrawal Both Causes Neurotoxicity and Inhibits Neuronal Recovery Processes in Rat Organotypic Hippocampal Cultures, (3) Binge Drinking-Induced Brain Damage: Genetic and Age Related Effects, (4) Binge Ethanol-Induced Brain Damage: Involvement of Edema, Arachidonic Acid and Tissue Necrosis Factor α (TNFα), and (5) Cyclic AMP Cascade, Stem Cells and Ethanol. Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal.
AB - This manuscript reviews the proceedings of a symposium organized by Drs. Antonio Noronha and Fulton Crews presented at the 2003 Research Society on Alcoholism meeting. The purpose of the symposium was to examine recent findings on when alcohol induced brain damage occurs, e.g., during intoxication and/or during alcohol withdrawal. Further studies investigate specific brain regions (where) and the mechanisms (why) of alcoholic neurodegeneration. The presentations were (1) Characterization of Synaptic Loss in Cerebella of Mature and Senescent Rats after Lengthy Chronic Ethanol Consumption, (2) Ethanol Withdrawal Both Causes Neurotoxicity and Inhibits Neuronal Recovery Processes in Rat Organotypic Hippocampal Cultures, (3) Binge Drinking-Induced Brain Damage: Genetic and Age Related Effects, (4) Binge Ethanol-Induced Brain Damage: Involvement of Edema, Arachidonic Acid and Tissue Necrosis Factor α (TNFα), and (5) Cyclic AMP Cascade, Stem Cells and Ethanol. Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal.
KW - Brain damage
KW - Ethanol
KW - Stem dells
KW - TNFα
KW - Withdrawal
UR - http://www.scopus.com/inward/record.url?scp=10744222407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744222407&partnerID=8YFLogxK
U2 - 10.1097/01.ALC.0000113416.65546.01
DO - 10.1097/01.ALC.0000113416.65546.01
M3 - Article
C2 - 15112943
AN - SCOPUS:10744222407
SN - 0145-6008
VL - 28
SP - 350
EP - 364
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
IS - 2
ER -
