Alcohol-Induced Neurodegeneration: When, Where and Why?

Fulton T. Crews, Michael A. Collins, Cynthia Dlugos, John Littleton, Lincoln Wilkins, Edward J. Neafsey, Roberta Pentney, Lawrence D. Snell, Boris Tabakoff, Jian Zou, Antonio Noronha

Research output: Contribution to journalArticlepeer-review

139 Scopus citations

Abstract

This manuscript reviews the proceedings of a symposium organized by Drs. Antonio Noronha and Fulton Crews presented at the 2003 Research Society on Alcoholism meeting. The purpose of the symposium was to examine recent findings on when alcohol induced brain damage occurs, e.g., during intoxication and/or during alcohol withdrawal. Further studies investigate specific brain regions (where) and the mechanisms (why) of alcoholic neurodegeneration. The presentations were (1) Characterization of Synaptic Loss in Cerebella of Mature and Senescent Rats after Lengthy Chronic Ethanol Consumption, (2) Ethanol Withdrawal Both Causes Neurotoxicity and Inhibits Neuronal Recovery Processes in Rat Organotypic Hippocampal Cultures, (3) Binge Drinking-Induced Brain Damage: Genetic and Age Related Effects, (4) Binge Ethanol-Induced Brain Damage: Involvement of Edema, Arachidonic Acid and Tissue Necrosis Factor α (TNFα), and (5) Cyclic AMP Cascade, Stem Cells and Ethanol. Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal.

Original languageEnglish
Pages (from-to)350-364
Number of pages15
JournalAlcoholism: Clinical and Experimental Research
Volume28
Issue number2
DOIs
StatePublished - Feb 2004

Keywords

  • Brain damage
  • Ethanol
  • Stem dells
  • TNFα
  • Withdrawal

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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