Alkaloids from the antarctic sponge Kirkpatrickia varialosa. Part 1: Variolin b, a new antitumour and antiviral compound

Nigel B. Perry; Laurent Ettouati; Marc Litaudon; John W. Blunt; Murray H.G. Munro; Sean Parkin; Hakon Hope

doi:10.1016/S0040-4020(01)89673-3

Alkaloids from the antarctic sponge Kirkpatrickia varialosa. Part 1: Variolin b, a new antitumour and antiviral compound

Nigel B. Perry, Laurent Ettouati, Marc Litaudon, John W. Blunt, Murray H.G. Munro, Sean Parkin, Hakon Hope

Chemistry

Research output: Contribution to journal › Article › peer-review

181 Scopus citations

Abstract

Variolin B (1), a new type of pyridopyrrolopyrimidine alkaloid with antitumour and antiviral properties, has been isolated from the Antarctic sponge Kirkpatrickia varialosa, and its structure determined by X-ray crystallography. A degradation product, variolin D (2), has been identified from its spectroscopic data.

Original language	English
Pages (from-to)	3987-3992
Number of pages	6
Journal	Tetrahedron
Volume	50
Issue number	13
DOIs	https://doi.org/10.1016/S0040-4020(01)89673-3
State	Published - Mar 28 1994

Bibliographical note

Funding Information:
We thank Mrs G. Barns for assays, Dr L.K. Pannell (NIDDK, spectroscopy, Dr W.T. Robinson for assistance with X-ray computations, collections, and PharmaMar SA for financial support.

Funding

We thank Mrs G. Barns for assays, Dr L.K. Pannell (NIDDK, spectroscopy, Dr W.T. Robinson for assistance with X-ray computations, collections, and PharmaMar SA for financial support.

Funders	Funder number
National Institute of Diabetes and Digestive and Kidney Diseases
Pharmamar-SAU

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Alkaloids from the antarctic sponge Kirkpatrickia varialosa. Part 1: Variolin b, a new antitumour and antiviral compound",

abstract = "Variolin B (1), a new type of pyridopyrrolopyrimidine alkaloid with antitumour and antiviral properties, has been isolated from the Antarctic sponge Kirkpatrickia varialosa, and its structure determined by X-ray crystallography. A degradation product, variolin D (2), has been identified from its spectroscopic data.",

author = "Perry, {Nigel B.} and Laurent Ettouati and Marc Litaudon and Blunt, {John W.} and Munro, {Murray H.G.} and Sean Parkin and Hakon Hope",

note = "Funding Information: We thank Mrs G. Barns for assays, Dr L.K. Pannell (NIDDK, spectroscopy, Dr W.T. Robinson for assistance with X-ray computations, collections, and PharmaMar SA for financial support.",

year = "1994",

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doi = "10.1016/S0040-4020(01)89673-3",

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T1 - Alkaloids from the antarctic sponge Kirkpatrickia varialosa. Part 1

T2 - Variolin b, a new antitumour and antiviral compound

AU - Perry, Nigel B.

AU - Ettouati, Laurent

AU - Litaudon, Marc

AU - Blunt, John W.

AU - Munro, Murray H.G.

AU - Parkin, Sean

AU - Hope, Hakon

N1 - Funding Information: We thank Mrs G. Barns for assays, Dr L.K. Pannell (NIDDK, spectroscopy, Dr W.T. Robinson for assistance with X-ray computations, collections, and PharmaMar SA for financial support.

PY - 1994/3/28

Y1 - 1994/3/28

N2 - Variolin B (1), a new type of pyridopyrrolopyrimidine alkaloid with antitumour and antiviral properties, has been isolated from the Antarctic sponge Kirkpatrickia varialosa, and its structure determined by X-ray crystallography. A degradation product, variolin D (2), has been identified from its spectroscopic data.

AB - Variolin B (1), a new type of pyridopyrrolopyrimidine alkaloid with antitumour and antiviral properties, has been isolated from the Antarctic sponge Kirkpatrickia varialosa, and its structure determined by X-ray crystallography. A degradation product, variolin D (2), has been identified from its spectroscopic data.

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U2 - 10.1016/S0040-4020(01)89673-3

DO - 10.1016/S0040-4020(01)89673-3

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VL - 50

SP - 3987

EP - 3992

JO - Tetrahedron

JF - Tetrahedron

IS - 13

ER -

Alkaloids from the antarctic sponge Kirkpatrickia varialosa. Part 1: Variolin b, a new antitumour and antiviral compound

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

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