Alloantibody to a Bw4 epitope in a Bw4+ B∗27:05 patient

Charles T. Lutz, Ahmad Al-Attar, John R. May, C. Darrell Jennings

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background. Alloantibodies to the Bw4 epitope are known to be heterogeneous, but it is widely assumed that anti-Bw4 alloantibodies arise only in individuals who do not express a Bw4 epitope. Methods. Bw4 expression was confirmed by DNA sequence analysis. Anti-Bw4 reactivity was confirmed by absorption with transfected cells. Results. A Bw4+ (B∗27:05 or B∗27:13) patient expressed antibody that bound all Bw4+ human leukocyte antigen-A and human leukocyte antigen-B antigens tested, except B∗27:05 and B∗44:02. Serum absorbed with B∗51:01-transfected HYM2.C1R cells left only reactivity to B17 (B57, B58), but not to any other Bw4+ antigens. Conclusion. A Bw4+ patient made antibody to a Bw4 epitope. This finding indicates that apparent anti-Bw4 or anti-Bw6 antibody should not be ignored even in patients who express a common Bw4+ or Bw6+ antigen, respectively.

Original languageEnglish
Pages (from-to)853-856
Number of pages4
Issue number8
StatePublished - 2014

Bibliographical note

Publisher Copyright:
© 2014 Lippincott Williams & Wilkins.


  • Antibody
  • Bw4 epitope
  • Histocompatibility
  • Transplantation

ASJC Scopus subject areas

  • Transplantation


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