Abstract
The current research examined the regulation of synaptic strength by protein phosphorylation during aging. Bath application of the protein phosphatase 1 and 2A (PP1 and PP2A) inhibitor calyculin A (1 μM) enhanced CA3-CA1 synaptic strength in hippocampal slices from aged male (20-24 mo) but not from young adult male (4-6 mo) Fischer 344 rats. Similarly, injection of the PP1 and PP2A inhibitor microcystin-L,R (5 μM) into CA1 cells caused an increase in the intracellular synaptic response only in slices from aged rats. In contrast, bath application of the serine/threonine kinase inhibitor H-7 (10 μM) induced a decrease in synaptic strength only in slices from the young adult group. These results demonstrate that phosphorylation-dependent regulation of intrinsic synaptic efficacy changes during aging.
Original language | English |
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Pages (from-to) | 1567-1570 |
Number of pages | 4 |
Journal | Journal of Neurophysiology |
Volume | 80 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1998 |
ASJC Scopus subject areas
- Neuroscience (all)
- Physiology