Altered distribution of excitatory amino acid receptors in temporal lobe epilepsy

James W. Geddes, Leslie D. Gahan, Suzanne M. Cooper, Ronald C. Kim, Ben H. Choi, Carl W. Cotman

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


In temporal lobe epilepsy, excitatory amino acid receptors in the hippocampus and temporal lobe may contribute to both increased excitability and vulnerability to excitotoxic damage. We used receptor autoradiography to examine the density of N-methyl-d-aspartate (NMDA) and kainic acid (KA) receptors in the hippocampus and parahippocampal gyrus obtained from five patients who had undergone anterior temporal lobectomy for the treatment of intractable seizures and from six control individuals, in which the hippocampus was obtained postmortem. Within the hippocampal formation, loss of [3H]KA and NMDA-sensitive l-[3H]glutamate binding was apparent in the sclerotic regions CA3, hilus, and CA1. In the subiculum and molecular layer of the denate gyrus, binding densities were maintained or even increased in some of the epileptic patients. A two-fold increase in l-[3H]glutamate binding, along with an increase in [3H]KA binding, was observed in the parahippocampal gyrus obtained from the epileptic patients. The results suggest that the vulnerability of the hippocampus in temporal lobe epilepsy may result, at least in part, from the presence of aberrant excitatory circuits in the parahippocampal gyrus.

Original languageEnglish
Pages (from-to)214-220
Number of pages7
JournalExperimental Neurology
Issue number3
StatePublished - Jun 1990

Bibliographical note

Funding Information:
This research was supported Foundation and by NIMH Grant

Copyright 2014 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


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