Altered energy metabolism in cancer: A unique opportunity for therapeutic intervention

Yi Zhang, Jin Ming Yang

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations

Abstract

The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the peculiar metabolic pathways in cancer might be an effective strategy for cancer therapy. In recent years, investigations have accelerated into how altered cellular metabolism promotes tumor survival and growth. This review highlights the current concepts of altered metabolism in cancer and the molecular targets involved in glycolysis, mitochondria and glutamine metabolism and discusses future perspective of cellular metabolism-based cancer treatment.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalCancer Biology and Therapy
Volume14
Issue number2
DOIs
StatePublished - Feb 2013

Bibliographical note

Funding Information:
This manuscript is supported by grants from National Natural Sciences Foundation of China (81072146), by a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and by US Public Health Service (R01CA135038).

Keywords

  • Cancer metabolism
  • Cancer therapy
  • Cell death
  • Cell survival

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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