Altered energy metabolism in cancer: A unique opportunity for therapeutic intervention

Yi Zhang; Jin Ming Yang

doi:10.4161/cbt.22958

Altered energy metabolism in cancer: A unique opportunity for therapeutic intervention

Yi Zhang, Jin Ming Yang

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the peculiar metabolic pathways in cancer might be an effective strategy for cancer therapy. In recent years, investigations have accelerated into how altered cellular metabolism promotes tumor survival and growth. This review highlights the current concepts of altered metabolism in cancer and the molecular targets involved in glycolysis, mitochondria and glutamine metabolism and discusses future perspective of cellular metabolism-based cancer treatment.

Original language	English
Pages (from-to)	81-89
Number of pages	9
Journal	Cancer Biology and Therapy
Volume	14
Issue number	2
DOIs	https://doi.org/10.4161/cbt.22958
State	Published - Feb 2013

Bibliographical note

Funding Information:
This manuscript is supported by grants from National Natural Sciences Foundation of China (81072146), by a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and by US Public Health Service (R01CA135038).

Keywords

Cancer metabolism
Cancer therapy
Cell death
Cell survival

ASJC Scopus subject areas

Molecular Medicine
Oncology
Pharmacology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/cbt.22958

Cite this

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title = "Altered energy metabolism in cancer: A unique opportunity for therapeutic intervention",

abstract = "The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the peculiar metabolic pathways in cancer might be an effective strategy for cancer therapy. In recent years, investigations have accelerated into how altered cellular metabolism promotes tumor survival and growth. This review highlights the current concepts of altered metabolism in cancer and the molecular targets involved in glycolysis, mitochondria and glutamine metabolism and discusses future perspective of cellular metabolism-based cancer treatment.",

keywords = "Cancer metabolism, Cancer therapy, Cell death, Cell survival",

author = "Yi Zhang and Yang, {Jin Ming}",

note = "Funding Information: This manuscript is supported by grants from National Natural Sciences Foundation of China (81072146), by a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and by US Public Health Service (R01CA135038).",

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T2 - A unique opportunity for therapeutic intervention

AU - Zhang, Yi

AU - Yang, Jin Ming

N1 - Funding Information: This manuscript is supported by grants from National Natural Sciences Foundation of China (81072146), by a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and by US Public Health Service (R01CA135038).

PY - 2013/2

Y1 - 2013/2

N2 - The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the peculiar metabolic pathways in cancer might be an effective strategy for cancer therapy. In recent years, investigations have accelerated into how altered cellular metabolism promotes tumor survival and growth. This review highlights the current concepts of altered metabolism in cancer and the molecular targets involved in glycolysis, mitochondria and glutamine metabolism and discusses future perspective of cellular metabolism-based cancer treatment.

AB - The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the peculiar metabolic pathways in cancer might be an effective strategy for cancer therapy. In recent years, investigations have accelerated into how altered cellular metabolism promotes tumor survival and growth. This review highlights the current concepts of altered metabolism in cancer and the molecular targets involved in glycolysis, mitochondria and glutamine metabolism and discusses future perspective of cellular metabolism-based cancer treatment.

KW - Cancer metabolism

KW - Cancer therapy

KW - Cell death

KW - Cell survival

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Altered energy metabolism in cancer: A unique opportunity for therapeutic intervention

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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