Abstract
The early observations by Dr Otto Warburg revealed that fundamentally metabolic differences exist between malignant tumor cells and adjacent normal cells. Many studies have further reported the relationship between altered cellular metabolism and therapeutic outcomes. These observations suggest that targeting the peculiar metabolic pathways in cancer might be an effective strategy for cancer therapy. In recent years, investigations have accelerated into how altered cellular metabolism promotes tumor survival and growth. This review highlights the current concepts of altered metabolism in cancer and the molecular targets involved in glycolysis, mitochondria and glutamine metabolism and discusses future perspective of cellular metabolism-based cancer treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 81-89 |
| Number of pages | 9 |
| Journal | Cancer Biology and Therapy |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2013 |
Bibliographical note
Funding Information:This manuscript is supported by grants from National Natural Sciences Foundation of China (81072146), by a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and by US Public Health Service (R01CA135038).
Funding
This manuscript is supported by grants from National Natural Sciences Foundation of China (81072146), by a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and by US Public Health Service (R01CA135038).
| Funders | Funder number |
|---|---|
| National Childhood Cancer Registry – National Cancer Institute | R01CA135038 |
| U.S. Public Health Service | |
| National Natural Science Foundation of China (NSFC) | 81072146 |
| Priority Academic Program Development of Jiangsu Higher Education Institutions |
Keywords
- Cancer metabolism
- Cancer therapy
- Cell death
- Cell survival
ASJC Scopus subject areas
- Molecular Medicine
- Oncology
- Pharmacology
- Cancer Research
