Altered expressions of fibroblast growth factor receptors and alveolarization in neonatal mice exposed to 85% oxygen

Min Soo Park, Esther Rieger-Fackeldey, Brandon L. Schanbacher, Angela C. Cook, John A. Bauer, Lynette K. Rogers, Thomas N. Hansen, Stephen E. Welty, Charles V. Smith

Research output: Contribution to journalArticlepeer-review

46 Citations (SciVal)

Abstract

In the present study, we tested the hypothesis that exposure of newborn mice to sublethal hyperoxia would alter lung development and expressions of fibroblast growth factor receptors (FGFRs)-3 and FGFR-4. Newborn FVB mice were exposed to 85% O2 or maintained in room air for up to 14 d. No animal mortality was observed, and body weight gains were not affected by hyperoxia. At postnatal d 7 and 14 (P7, P14), lungs of mice exposed to 85% O2 showed fewer alveolar secondary crests and larger alveoli or terminal air spaces than did mice in room air. In pups kept in room air, lung levels of FGFR-3 and FGFR-4 mRNA were greater at P3 than at P1, but similar increases were not observed in hyperoxic mice. Immunoreactivity of FGFR-3 and FGFR-4 was lower in lungs of hyperoxic mice than in controls at P14. In pups kept in room air, lung fibroblast growth factor (FGF)-7 mRNA levels were greater at P14 than at P1, but similar changes were not observed in hyperoxic mice. The temporally and spatially specific alterations in the expressions of FGFR-3, FGFR-4, and FGF-7 in the mice exposed to hyperoxia may contribute to aberrant lung development.

Original languageEnglish
Pages (from-to)652-657
Number of pages6
JournalPediatric Research
Volume62
Issue number6
DOIs
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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