Alternate approach to understanding the molecular mechanisms of stroke-induced injury

A. E. Willing, Keith R. Pennypacker

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Research in the area of stroke has not yielded any new treatments, besides tissue plasminogen activator. New findings are suggesting that the therapeutic window of providing neuroprotection is wider than once thought. Moreover, the role of the peripheral immune system in abetting neurodegeneration is being elucidated, but it appears this reaction occurs 2-3 days after the stroke. This mini-review examines this new evidence about the molecular mechanisms leading to stroke-induced neuronal death, which suggests new therapeutic approaches to its treatment.

Original languageEnglish
Pages (from-to)697-701
Number of pages5
JournalHistology and Histopathology
Issue number4-6
StatePublished - Apr 2007


  • Ischemia
  • Microglia
  • Neuronal death

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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