Alzheimer disease clinical trial recruitment

Justin M. Barber, Shoshana H. Bardach, Gregory A. Jicha

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Slow participant recruitment impedes Alzheimer disease research progress. Although research suggests that direct involvement with potential participants supports enrollment, strategies for how best to engage potential participants are still unclear. Purpose: This study explores whether community health fair (HF) attendees who engage in a brief cognitive screen (BCS) are more likely to enroll in research than attendees who do not complete a BCS. Subjects: A total of 483 HF attendees. Methods: Attendees were tracked for a 1-year period to ascertain research involvement. Results: In total, 364 attendees expressed interest in research and 126 completed a BCS. Over the follow-up period, 21 individuals prescreened as eligible and 19 enrolled in an investigational study. Among all HF attendees, BCS completers had a 2.5-fold increase in subsequently prescreening as eligible as compared with non-BCS completers. However, when limited only to participants who stated an interest in research, this difference was no longer significant. Conclusions: Completing a BCS at a community event may be an indicator of future research engagement, but for those already interested in participation, the BCS may be a poor indicator of future involvement. The BCS may also reduce anxiety and stigma around memory evaluation, which may translate into research engagement in the future.

Original languageEnglish
Pages (from-to)333-338
Number of pages6
JournalAlzheimer Disease and Associated Disorders
Issue number4
StatePublished - 2018

Bibliographical note

Funding Information:
Received for publication December 18, 2017; accepted May 23, 2018. From the *Sanders Brown Center on Aging; †Graduate Center for Ger-ontology, College of Public Health; and ‡Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY. Supported by the National Institute on Aging P30 AG028383. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The authors declare no conflicts of interest. Reprints: Shoshana H. Bardach, PhD, Sanders-Brown Center on Aging, 1030 South Broadway, Suite 5, Lexington, KY 40504 (e-mail: Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website, www. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

Publisher Copyright:
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.


  • brief cognitive screen
  • community outreach
  • recruitment
  • research engagement

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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