Alzheimer's amyloid β-peptide (1-42): Involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide

D. Allan Butterfield; Ashley I. Bush

doi:10.1016/j.neurobiolaging.2003.12.027

Alzheimer's amyloid β-peptide (1-42): Involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide

D. Allan Butterfield, Ashley I. Bush

Research output: Contribution to journal › Article › peer-review

127 Scopus citations

Abstract

In the interesting debate entitled "Challenging Views of Alzheimer's Disease II," we defended the position that factors such as oxygen, the single methionine residue of amyloid β-peptide(1-42) [Aβ(1-42)], and redox metal ions were important for the oxidative stress and neurotoxic properties of this peptide that is critically involved in the pathogenesis of Alzheimer's disease. This brief review summarizes some of our findings relevant to the role of the single methionine residue of Aβ(1-42) in the oxidative stress and neurotoxic properties of this peptide.

Original language	English
Pages (from-to)	563-568
Number of pages	6
Journal	Neurobiology of Aging
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.neurobiolaging.2003.12.027
State	Published - 2004

Bibliographical note

Funding Information:
This work was supported in part by NIH grants to DAB (AG-05119: AG-10836) and grants to AIB from NIH (RO1AG12686), the Alzheimer’s Association, and MHMRC.

Keywords

Amyloid
Methionine
Neurotoxicity
Oxidative stress
β-peptide

ASJC Scopus subject areas

Neuroscience (all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2003.12.027

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abstract = "In the interesting debate entitled {"}Challenging Views of Alzheimer's Disease II,{"} we defended the position that factors such as oxygen, the single methionine residue of amyloid β-peptide(1-42) [Aβ(1-42)], and redox metal ions were important for the oxidative stress and neurotoxic properties of this peptide that is critically involved in the pathogenesis of Alzheimer's disease. This brief review summarizes some of our findings relevant to the role of the single methionine residue of Aβ(1-42) in the oxidative stress and neurotoxic properties of this peptide.",

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AU - Butterfield, D. Allan

AU - Bush, Ashley I.

N1 - Funding Information: This work was supported in part by NIH grants to DAB (AG-05119: AG-10836) and grants to AIB from NIH (RO1AG12686), the Alzheimer’s Association, and MHMRC.

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Alzheimer's amyloid β-peptide (1-42): Involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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