Alzheimer's amyloid β-peptide (1-42): Involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide

D. Allan Butterfield, Ashley I. Bush

Research output: Contribution to journalArticlepeer-review

127 Scopus citations

Abstract

In the interesting debate entitled "Challenging Views of Alzheimer's Disease II," we defended the position that factors such as oxygen, the single methionine residue of amyloid β-peptide(1-42) [Aβ(1-42)], and redox metal ions were important for the oxidative stress and neurotoxic properties of this peptide that is critically involved in the pathogenesis of Alzheimer's disease. This brief review summarizes some of our findings relevant to the role of the single methionine residue of Aβ(1-42) in the oxidative stress and neurotoxic properties of this peptide.

Original languageEnglish
Pages (from-to)563-568
Number of pages6
JournalNeurobiology of Aging
Volume25
Issue number5
DOIs
StatePublished - 2004

Bibliographical note

Funding Information:
This work was supported in part by NIH grants to DAB (AG-05119: AG-10836) and grants to AIB from NIH (RO1AG12686), the Alzheimer’s Association, and MHMRC.

Keywords

  • Amyloid
  • Methionine
  • Neurotoxicity
  • Oxidative stress
  • β-peptide

ASJC Scopus subject areas

  • Neuroscience (all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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