In the interesting debate entitled "Challenging Views of Alzheimer's Disease II," we defended the position that factors such as oxygen, the single methionine residue of amyloid β-peptide(1-42) [Aβ(1-42)], and redox metal ions were important for the oxidative stress and neurotoxic properties of this peptide that is critically involved in the pathogenesis of Alzheimer's disease. This brief review summarizes some of our findings relevant to the role of the single methionine residue of Aβ(1-42) in the oxidative stress and neurotoxic properties of this peptide.
|Number of pages||6|
|Journal||Neurobiology of Aging|
|State||Published - 2004|
Bibliographical noteFunding Information:
This work was supported in part by NIH grants to DAB (AG-05119: AG-10836) and grants to AIB from NIH (RO1AG12686), the Alzheimer’s Association, and MHMRC.
- Oxidative stress
ASJC Scopus subject areas
- Neuroscience (all)
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology