Alzheimer's disease, dental amalgam and mercury

Stanley R. Saxe, Merle W. Wekstein, Richard J. Kryscio, Robert G. Henry, Charles R. Cornett, David A. Snowdon, Ford T. Grant, Frederick A. Schmitt, Sara Jean Donegan, David R. Wekstein, William D. Ehmann, William R. Markesbery

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74 Scopus citations


Background. Mercury, or Hg, is a neurotoxin that has been speculated to play a role in the pathogenesis of Alzheimer's disease, or AD. Dental amalgam releases low levels of Hg vapor and is a potential source of Hg for a large segment of the adult population. Methods. The authors studied 68 subjects with AD and 33 control subjects without AD to determine Hg levels in multiple brain regions at autopsy and to ascertain the subjects' dental amalgam status and history. The subjects were from central Kentucky and Elm Grove, Wis. The authors conducted dental amalgam assessments during the lives of the majority of subjects and in some subjects at the time of autopsy only. The authors also determined three dental amalgam index scores - Event (placement, repair or removal of amalgam), Location and Time In Mouth - in addition to the numbers of and surface area of occlusal amalgam restorations. The authors determined Hg levels in multiple brain regions and performed full neuropathologic evaluations to confirm the normal status of the brain or the presence of AD. Results. The authors found no significant association of AD with the number, surface area or history of having dental amalgam restorations. They also found no statistically significant differences in brain Hg level between subjects with AD and control subjects. Conclusions. Hg in dental amalgam restorations does not appear to be a neurotoxic factor in the pathogenesis of AD. The authors found that brain Hg levels are not associated with dental amalgam, either from existing amalgam restorations or according to subjects' dental amalgam restoration history. Clinical Implications. Dental amalgam restorations, regardless of number, occlusal surface area or time, do not relate to brain Hg levels.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalJournal of the American Dental Association
Issue number2
StatePublished - Feb 1999

Bibliographical note

Funding Information:
This work was supported by National Institute of Health grants RO1 AG 10664, 1-P01-AG 05119, 5-P50-AG 05144 and RO1 AG 09862.

ASJC Scopus subject areas

  • Dentistry (all)


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