Alzheimer'S disease: Monoamines and spiperone binding reduced in nucleus basalis

D. Larry Sparks, William R. Markesbery, John T. Slevin

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Levels of dopamine and serotonin, and of their precursors and metabolites, were measured in the nucleus basalis of Meynert (nbM) of patients with Alzheimer's disease and control patients. [3H]Spiperone binding to membrane homogenates of the nbM, indicative of both dopaminergic and serotonergic receptors, was also measured. The nbM from patients with Alzheimer's disease showed significant decreases in both spiperone binding and in the levels of dopamine and serotonin but no decrease in either tyrosine or tryptophan levels. These data indicate a loss of both dopaminergic and serotonergic synapses in the nbM of patients with Alzheimer's disease.

Original languageEnglish
Pages (from-to)602-604
Number of pages3
JournalAnnals of Neurology
Volume19
Issue number6
DOIs
StatePublished - Jun 1986

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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