Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Claire E. Sexton, Kaarin J. Anstey, Filippo Baldacci, C. J. Barnum, Anna M. Barron, Kaj Blennow, Henry Brodaty, Samantha Burnham, Fanny M. Elahi, Jürgen Götz, Yun Hee Jeon, Maya Koronyo-Hamaoui, Susan M. Landau, Nicola T. Lautenschlager, Simon M. Laws, Darren M. Lipnicki, Hanzhang Lu, Colin L. Masters, Wendy Moyle, Akinori NakamuraGiulio Maria Pasinetti, Naren Rao, Christopher Rowe, Perminder S. Sachdev, Peter R. Schofield, Einar M. Sigurdsson, Kate Smith, Velandai Srikanth, Cassandra Szoeke, Malú G. Tansey, Rachel Whitmer, Donna Wilcock, Tien Y. Wong, Lisa J. Bain, Maria C. Carrillo

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias. This leadership includes the Australian Imaging, Biomarker, and Lifestyle Flagship Study of Ageing (AIBL), which has fueled the identification and development of many biomarkers and novel therapeutics. Two multimodal lifestyle intervention studies have been launched in Australia; and Australian researchers have played leadership roles in other global studies in diverse populations. Australian researchers have also played an instrumental role in efforts to understand mechanisms underlying vascular contributions to cognitive impairment and dementia; and through the Women's Healthy Aging Project have elucidated hormonal and other factors that contribute to the increased risk of AD in women. Alleviating the behavioral and psychological symptoms of dementia has also been a strong research and clinical focus in Australia.

Original languageEnglish
Pages (from-to)178-190
Number of pages13
JournalAlzheimer's and Dementia
Volume18
Issue number1
DOIs
StatePublished - Jan 2022

Bibliographical note

Funding Information:
Since the AAIC‐SS in Sydney, the Alzheimer's Association and the Medical Research Future Fund have funded the launch and implementation of the Australian Multidomain Approach to Reduce Dementia Risk by Protecting Brain Health with Lifestyle Intervention (AU‐ARROW). The AU‐ARROW intervention and assessment model builds on AIBL research findings and a lifestyle intervention study that demonstrated improved cognition and increased cerebral glucose metabolism resulting from a combination of physical activity with computerized brain training. The 2‐year trial will be conducted in Sydney and Perth, comparing a multidomain intervention (aerobic exercise, nutritional counseling, computerized cognitive training, social engagement, and vascular risk monitoring) with a control group receiving health education and support. AU‐ARROW has been harmonized to the U.S. POINTER study, which is wholly funded and led in collaboration with the Alzheimer's Association. This coordination is a key aspect for both studies, and supported through WW FINGERS. 88

Funding Information:
Planning for the symposium was supported by NHMRC National Institute for Dementia Research (NNIDR). The authors wish to acknowledge the administrative team who provided significant support in the preparation of the report on its proceeding including Ms. Joanna Graca.

Funding Information:
Authors are supported in part by the following: K. Anstey: National Health and Medical Research Council Grants 1100579, 1102694. C.J. Barnum: Alzheimer's funding is a Part the Cloud Award. A. Barron: Nanyang Technological University Singapore; Alzheimer's Association (AARG‐18‐566427) and Singapore Ministry of Education (2018‐T1‐001‐041). K. Blennow: the Swedish Research Council (#2017‐00915), the Alzheimer Drug Discovery Foundation (ADDF), USA (#RDAPB‐201809‐2016615), the Swedish Alzheimer Foundation (#AF‐742881), Hjärnfonden, Sweden (#FO2017‐0243), the Swedish state under the agreement between the Swedish government and the County Councils, the ALF‐agreement (#ALFGBG‐715986), and European Union Joint Program for Neurodegenerative Disorders (JPND2019‐466‐236). H. Brodaty: funding for the Maintain Your Brain trial was provided by a National Health and Medical Research Council of Australia Program Boosting Dementia Research Team Grant APP1095097. Funding for the HALT study was provided by an Australian Department of Health Aged Care Services Improvement Healthy Ageing Grant. S. Burnham: National Health and Medical Research Council Grants 1156891, 1161706, 1191535. F. Elahi: New Vision Research Investigator Award (CCAD201903), Larry L. Hillblom Foundation (2019‐A‐012‐SUP), National Institutes of Health (UH3NS100608). Y.H. Jeon: the early implementation of StepUp for Dementia Research is supported by the Australian Government Department of Health under the Dementia and Aged Care Services Fund. M. Koronyo‐Hamaoui: National Institute on Aging (R01 AG055865 and R01 AG056478) and the Tom Gordon Private Foundation. S. Landau: National Institutes on Aging (R01 AG062542, R01 AG062689, U19 AG024904). N. Lautenschlager: National Health and Medical Research Council Grants 1005942, 1045530, 1100579. S. Laws: National Medical Health and Research Council (APP1161706, APP1191535, APP1151854). D. Lipnicki: funding for COSMIC comes from National Health and Medical Research Council of Australia Program Grant (ID 1093083) (PSS, HB), the National Institute On Aging of the National Institutes of Health under Award Number RF1AG057531 (PSS, MG, RBL, KR, KWK, HB), and philanthropic contributions to The Dementia Momentum Fund (UNSW Project ID PS38235). H. Lu: National Institutes of Health (UH3 NS100588, R01 AG064792). W. Moyle: funding for the Effect of an Interactive Therapeutic Robotic Animal on Engagement, Mood States, Agitation and Antipsychotic Drug Use was provided by a National Health and Medical Research Council Project Grant APP1065320; funding for The effect of PARO on social engagement, communication and quality of life in people living with dementia in residential care was provided by a Alzheimer's Australia Research Grant; piloting a Telepresence Robot: Feasibility and impact on the person with dementia and family was funded by a Dementia Collaborative Research Special Project Research Grant. A. Nakamura: Research and Development Grants for Dementia from the Japan Agency for Medical Research and Development, AMED. G. Pasinetti: funding provided by the P50 AT008661‐01 from the National Center for Complementary and Integrative Health (NCCIH) and the Office of Dietary Supplements (ODS) and support from the Altschul Foundation. In addition, J.W. and G.M.P. hold positions in the Research and Development Unit of the Basic and Biomedical Research and Training Program, GRECC and G.M.P are a VA Senior Research Career Scientist at the James J. Peters Veterans Affairs Medical Center. We acknowledge that the contents of this manuscript are solely the responsibility of the authors and do not necessarily represent the views of the NCCIH or the U.S. Department of Veterans Affairs or the United States Government. N. Rao: Tata trusts and Centre for Brain Research. P. Sachdev: grant funding from the NHMRC and the NIA/NIH. P. Schofield: National Medical Health and Research Council (Australia) 1176716. E. Sigurdsson: National Institutes of Health, R01 NS077239, R01 AG032611, R21 AG059391, R21 AG058282. V. Srikanth: National Health and Medical Research Council Practitioner Fellowship (APP1137837). C. Szoeke: National Medical Health and Research Council (547500, 1032350, and 1062133), the Royal Australasian College of Physicians, the Alzheimer's Association (NIRG‐14‐320312). D. Wilcock: NINDS UH3NS100606, RO1NS097722; NIA RF1AG057754. M. Tansey: National Institutes of Health (1R01‐AG‐057247, 5R01‐NS‐092122, 3RF1‐AG‐051514) and an endowment from the Norman Fixel Institute for Neurological Diseases at the University of Florida.

Publisher Copyright:
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

Keywords

  • Alzheimer's
  • behavioral symptoms
  • biomarkers
  • dementia
  • prevention

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

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