Amelioration of relapsing polychondritis in a child treated with oral collagen

M. J. Navarro, G. C. Higgins, K. M. Lohr, L. K. Myers

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Relapsing polychondritis (RP) is a disease characterized by inflammation and the destruction of cartilage. The detection of antibodies to native type II collagen (CII) in the sera of some patients with relapsing polychondritis suggests that autoimmunity to this cartilage specific protein plays a role in the pathogenesis of the disease. RP is so rare that controlled therapeutic trials have not been carried out. We describe herein a child with RP who had amelioration of symptoms and a deviation in the cellular immune response to CII after being treated with daily oral CII as a toleragen.

Original languageEnglish
Pages (from-to)101-103
Number of pages3
JournalAmerican Journal of the Medical Sciences
Volume324
Issue number2
DOIs
StatePublished - 2002

Bibliographical note

Funding Information:
This work was supported, in part, by United States Public Health Service grant AR43589 and program-directed funds from the Arthritis Foundation.

Keywords

  • Autoimmunity
  • Cytokines
  • Oral tolerance
  • Relapsing polychondritis
  • Type II collagen

ASJC Scopus subject areas

  • General Medicine

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