Amelioration of relapsing polychondritis in a child treated with oral collagen

M. J. Navarro; G. C. Higgins; K. M. Lohr; L. K. Myers

doi:10.1097/00000441-200208000-00009

Amelioration of relapsing polychondritis in a child treated with oral collagen

M. J. Navarro, G. C. Higgins, K. M. Lohr, L. K. Myers

Internal Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Relapsing polychondritis (RP) is a disease characterized by inflammation and the destruction of cartilage. The detection of antibodies to native type II collagen (CII) in the sera of some patients with relapsing polychondritis suggests that autoimmunity to this cartilage specific protein plays a role in the pathogenesis of the disease. RP is so rare that controlled therapeutic trials have not been carried out. We describe herein a child with RP who had amelioration of symptoms and a deviation in the cellular immune response to CII after being treated with daily oral CII as a toleragen.

Original language	English
Pages (from-to)	101-103
Number of pages	3
Journal	American Journal of the Medical Sciences
Volume	324
Issue number	2
DOIs	https://doi.org/10.1097/00000441-200208000-00009
State	Published - 2002

Bibliographical note

Funding Information:
This work was supported, in part, by United States Public Health Service grant AR43589 and program-directed funds from the Arthritis Foundation.

Funding

This work was supported, in part, by United States Public Health Service grant AR43589 and program-directed funds from the Arthritis Foundation.

Funders	Funder number
Arthritis Foundation
U.S. Public Health Service	AR43589

Keywords

Autoimmunity
Cytokines
Oral tolerance
Relapsing polychondritis
Type II collagen

ASJC Scopus subject areas

General Medicine

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10.1097/00000441-200208000-00009

Cite this

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title = "Amelioration of relapsing polychondritis in a child treated with oral collagen",

abstract = "Relapsing polychondritis (RP) is a disease characterized by inflammation and the destruction of cartilage. The detection of antibodies to native type II collagen (CII) in the sera of some patients with relapsing polychondritis suggests that autoimmunity to this cartilage specific protein plays a role in the pathogenesis of the disease. RP is so rare that controlled therapeutic trials have not been carried out. We describe herein a child with RP who had amelioration of symptoms and a deviation in the cellular immune response to CII after being treated with daily oral CII as a toleragen.",

keywords = "Autoimmunity, Cytokines, Oral tolerance, Relapsing polychondritis, Type II collagen",

author = "Navarro, {M. J.} and Higgins, {G. C.} and Lohr, {K. M.} and Myers, {L. K.}",

note = "Funding Information: This work was supported, in part, by United States Public Health Service grant AR43589 and program-directed funds from the Arthritis Foundation. ",

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AU - Navarro, M. J.

AU - Higgins, G. C.

AU - Lohr, K. M.

AU - Myers, L. K.

N1 - Funding Information: This work was supported, in part, by United States Public Health Service grant AR43589 and program-directed funds from the Arthritis Foundation.

PY - 2002

Y1 - 2002

N2 - Relapsing polychondritis (RP) is a disease characterized by inflammation and the destruction of cartilage. The detection of antibodies to native type II collagen (CII) in the sera of some patients with relapsing polychondritis suggests that autoimmunity to this cartilage specific protein plays a role in the pathogenesis of the disease. RP is so rare that controlled therapeutic trials have not been carried out. We describe herein a child with RP who had amelioration of symptoms and a deviation in the cellular immune response to CII after being treated with daily oral CII as a toleragen.

AB - Relapsing polychondritis (RP) is a disease characterized by inflammation and the destruction of cartilage. The detection of antibodies to native type II collagen (CII) in the sera of some patients with relapsing polychondritis suggests that autoimmunity to this cartilage specific protein plays a role in the pathogenesis of the disease. RP is so rare that controlled therapeutic trials have not been carried out. We describe herein a child with RP who had amelioration of symptoms and a deviation in the cellular immune response to CII after being treated with daily oral CII as a toleragen.

KW - Autoimmunity

KW - Cytokines

KW - Oral tolerance

KW - Relapsing polychondritis

KW - Type II collagen

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JF - American Journal of the Medical Sciences

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Amelioration of relapsing polychondritis in a child treated with oral collagen

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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