As part of a drug discovery program using high-throughput radioligand-binding assays, aminoanthraquinones were identified as potential modulators of N-methyl-D-aspartate (NMDA) receptor function. Aminoanthraquinones may represent a novel class of polyamine binding site ligands with a unique pharmacophore and may facilitate the rational design of novel NMDA-receptor modulators. (C) 2000 Elsevier Science Ltd.
|Number of pages||3|
|Journal||Bioorganic and Medicinal Chemistry Letters|
|State||Published - Dec 4 2000|
Bibliographical noteFunding Information:
Supported by American Foundation for Pharmaceutical Education Fellowships (AKB and DRW) and National Institute of Alcohol Abuse and Alcoholism Grant #AA12600. The authors also acknowledge the NIH Anticonvulsant Drug Development program (Epilepsy Branch, National Institute of Neurological Disorders and Stroke) for their role in the neurotoxicity assessment.
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry