Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex

Aimee K. Bence; Dennis T. Rogers; David R. Worthen; May Fu; John M. Littleton; Peter A. Crooks

doi:10.1016/S0960-894X(00)00530-8

Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex

Aimee K. Bence, Dennis T. Rogers, David R. Worthen, May Fu, John M. Littleton, Peter A. Crooks

Psychology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

As part of a drug discovery program using high-throughput radioligand-binding assays, aminoanthraquinones were identified as potential modulators of N-methyl-D-aspartate (NMDA) receptor function. Aminoanthraquinones may represent a novel class of polyamine binding site ligands with a unique pharmacophore and may facilitate the rational design of novel NMDA-receptor modulators. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	2621-2623
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(00)00530-8
State	Published - Dec 4 2000

Bibliographical note

Funding Information:
Supported by American Foundation for Pharmaceutical Education Fellowships (AKB and DRW) and National Institute of Alcohol Abuse and Alcoholism Grant #AA12600. The authors also acknowledge the NIH Anticonvulsant Drug Development program (Epilepsy Branch, National Institute of Neurological Disorders and Stroke) for their role in the neurotoxicity assessment.

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00530-8

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title = "Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex",

abstract = "As part of a drug discovery program using high-throughput radioligand-binding assays, aminoanthraquinones were identified as potential modulators of N-methyl-D-aspartate (NMDA) receptor function. Aminoanthraquinones may represent a novel class of polyamine binding site ligands with a unique pharmacophore and may facilitate the rational design of novel NMDA-receptor modulators. (C) 2000 Elsevier Science Ltd.",

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AU - Bence, Aimee K.

AU - Rogers, Dennis T.

AU - Worthen, David R.

AU - Fu, May

AU - Littleton, John M.

AU - Crooks, Peter A.

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Y1 - 2000/12/4

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Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex

Abstract

Bibliographical note

ASJC Scopus subject areas

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