Amyloid β-peptide inhibits Na+-dependent glutamate uptake

Christopher M. Lauderback, Marni E. Harris-White, Yaning Wang, Norman W. Pedigo, John M. Carney, D. Allan Butterfield

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The purpose of this review is to summarize much of the work on the inhibition of the astroglial glutamate transporter in relation to excitotoxic neurodegeneration, in particular, inhibition of uptake by the β-amyloid peptide (Aβ) found in the Alzheimer's disease (AD) brain. There is evidence for oxidative stress in the AD brain, and Aβ has been found to generate reactive oxygen species (ROS), thus adding to the stress or possibly initiating it. The oxidative inhibition of the glutamate transporter protein by Aβ increases the vulnerability of glutamatergic neurons, and by rendering them susceptible to the excitotoxic insult that results from impaired glutamate uptake, Aβ can be directly connected to the neurodegeneration that follows.

Original languageEnglish
Pages (from-to)1977-1981
Number of pages5
JournalLife Sciences
Issue number18-19
StatePublished - Oct 1 1999


  • Excitotoxicity
  • Free radicals
  • Glutamate uptake
  • β-Amyloid

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology


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