Amyloid beta peptide, 4-hydroxynonenal and apoptosis

Mark A. Lovell, William R. Markesbery

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Considerable evidence suggests a role for oxidative stress in the pathogenesis of neuron degeneration in several neurodegenerative disorders including Alzheimer's disease (AD). Although debated, increasing evidence suggests that oxidative stress/damage (amyloid beta peptide, iron/hydrogen peroxide) or neurotoxic by-products of lipid peroxidation (4-hydroxy-2-nonenal, acrolein) lead to cell death through apoptosis or programmed cell death in AD. This review discusses current evidence supporting the role of oxidative stress/damage mediated apoptosis in in vitro models of neurodegeneration.

Original languageEnglish
Pages (from-to)359-364
Number of pages6
JournalCurrent Alzheimer Research
Issue number4
StatePublished - 2006

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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