TY - JOUR
T1 - Amyloid beta peptide, 4-hydroxynonenal and apoptosis
AU - Lovell, Mark A.
AU - Markesbery, William R.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006
Y1 - 2006
N2 - Considerable evidence suggests a role for oxidative stress in the pathogenesis of neuron degeneration in several neurodegenerative disorders including Alzheimer's disease (AD). Although debated, increasing evidence suggests that oxidative stress/damage (amyloid beta peptide, iron/hydrogen peroxide) or neurotoxic by-products of lipid peroxidation (4-hydroxy-2-nonenal, acrolein) lead to cell death through apoptosis or programmed cell death in AD. This review discusses current evidence supporting the role of oxidative stress/damage mediated apoptosis in in vitro models of neurodegeneration.
AB - Considerable evidence suggests a role for oxidative stress in the pathogenesis of neuron degeneration in several neurodegenerative disorders including Alzheimer's disease (AD). Although debated, increasing evidence suggests that oxidative stress/damage (amyloid beta peptide, iron/hydrogen peroxide) or neurotoxic by-products of lipid peroxidation (4-hydroxy-2-nonenal, acrolein) lead to cell death through apoptosis or programmed cell death in AD. This review discusses current evidence supporting the role of oxidative stress/damage mediated apoptosis in in vitro models of neurodegeneration.
UR - http://www.scopus.com/inward/record.url?scp=33748457094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748457094&partnerID=8YFLogxK
U2 - 10.2174/156720506778249506
DO - 10.2174/156720506778249506
M3 - Review article
C2 - 17017866
AN - SCOPUS:33748457094
SN - 1567-2050
VL - 3
SP - 359
EP - 364
JO - Current Alzheimer Research
JF - Current Alzheimer Research
IS - 4
ER -