An alcohol model of impaired inhibitory control and its treatment in humans

Mark T. Fillmore, M. Vogel-Sprott

Research output: Contribution to journalArticlepeer-review

158 Scopus citations


This study developed a model of impaired inhibitory control in humans to test the efficacy of treatments for this deficit. Male social drinkers (N = 35) practiced a 'go-stop' task that measured response inhibition. They then were assigned to 1 of 5 groups (n = 7) that performed the task under a different treatment. The model of impaired inhibitory control was provided by administering 0.62 g/kg alcohol to 1 group (A), whose response inhibition was compared with a placebo group (P). The other 3 groups received 0.62 g/kg alcohol plus a treatment designed to ameliorate alcohol impairment of inhibitory control: behavioral reinforcement (B), or 4.4 mg/kg caffeine (C), or a combination of both (B +C). Alcohol impaired inhibitory control, and all 3 treatments (B, C, and B+C) counteracted the impairment. The findings indicate that alcohol impairment of response inhibition may provide a useful human model to test conditions that may ameliorate or exacerbate deficits in behavioral control induced by drugs or other factors.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalExperimental and Clinical Psychopharmacology
Issue number1
StatePublished - Feb 1999

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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