TY - JOUR
T1 - An alcohol model of impaired inhibitory control and its treatment in humans
AU - Fillmore, Mark T.
AU - Vogel-Sprott, M.
PY - 1999/2
Y1 - 1999/2
N2 - This study developed a model of impaired inhibitory control in humans to test the efficacy of treatments for this deficit. Male social drinkers (N = 35) practiced a 'go-stop' task that measured response inhibition. They then were assigned to 1 of 5 groups (n = 7) that performed the task under a different treatment. The model of impaired inhibitory control was provided by administering 0.62 g/kg alcohol to 1 group (A), whose response inhibition was compared with a placebo group (P). The other 3 groups received 0.62 g/kg alcohol plus a treatment designed to ameliorate alcohol impairment of inhibitory control: behavioral reinforcement (B), or 4.4 mg/kg caffeine (C), or a combination of both (B +C). Alcohol impaired inhibitory control, and all 3 treatments (B, C, and B+C) counteracted the impairment. The findings indicate that alcohol impairment of response inhibition may provide a useful human model to test conditions that may ameliorate or exacerbate deficits in behavioral control induced by drugs or other factors.
AB - This study developed a model of impaired inhibitory control in humans to test the efficacy of treatments for this deficit. Male social drinkers (N = 35) practiced a 'go-stop' task that measured response inhibition. They then were assigned to 1 of 5 groups (n = 7) that performed the task under a different treatment. The model of impaired inhibitory control was provided by administering 0.62 g/kg alcohol to 1 group (A), whose response inhibition was compared with a placebo group (P). The other 3 groups received 0.62 g/kg alcohol plus a treatment designed to ameliorate alcohol impairment of inhibitory control: behavioral reinforcement (B), or 4.4 mg/kg caffeine (C), or a combination of both (B +C). Alcohol impaired inhibitory control, and all 3 treatments (B, C, and B+C) counteracted the impairment. The findings indicate that alcohol impairment of response inhibition may provide a useful human model to test conditions that may ameliorate or exacerbate deficits in behavioral control induced by drugs or other factors.
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U2 - 10.1037/1064-1297.7.1.49
DO - 10.1037/1064-1297.7.1.49
M3 - Article
C2 - 10036609
AN - SCOPUS:0033048498
SN - 1064-1297
VL - 7
SP - 49
EP - 55
JO - Experimental and Clinical Psychopharmacology
JF - Experimental and Clinical Psychopharmacology
IS - 1
ER -
