An animal model of capsular infarct: Endothelin-1 injections in the rat

Shawn B. Frost, Scott Barbay, Michael L. Mumert, Ann M. Stowe, Randolph J. Nudo

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


In this study stereotaxic injections of the vasoconstrictive peptide endothelin-1 (ET-1) were used to create infarcts in the white matter of the internal capsule underlying sensorimotor cortex in rats. Resulting deficits were assessed using established sensorimotor tests conducted on each rat before and after the ET-1-induced infarct. After a 14-day survival period, histological examination revealed tissue necrosis and demyelination in the infarcted white matter of ET-1-injected rats, but not saline-injected control rats. Infarcts resulted in measurable sensorimotor deficits in rats that received ET-1 injections. The same sensorimotor tests showed no deficits in surgical-control rats. The present model of white matter infarct should be valuable in examining the underlying mechanisms of subcortical ischemic stroke and to evaluate potential therapeutic interventions.

Original languageEnglish
Pages (from-to)206-211
Number of pages6
JournalBehavioural Brain Research
Issue number2
StatePublished - May 15 2006

Bibliographical note

Funding Information:
We would like to thank Angela Link and Robert Cross for assistance in this project. We would also like to thank DeAnna Adkins and Theresa Jones for advice on the use of ET-1. Supported by NIH NS 30853 (RJN), American Heart Association Grant 0120624Z (SBF), and Center Grants HD07523 and NICHD HD02528.


  • Animal model
  • Capsular-infarct
  • Endothelin-1
  • White-matter

ASJC Scopus subject areas

  • Behavioral Neuroscience


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