An Assessment of the severity of interstitial pancreatitis

Vikesh K. Singh, Thomas L. Bollen, Bechien U. Wu, Kathryn Repas, Rie Maurer, Song Yu, Koenraad J. Mortele, Darwin L. Conwell, Peter A. Banks

Research output: Contribution to journalArticlepeer-review

136 Scopus citations


Background & Aims: There is limited information on the incidence of and factors associated with severe disease among patients with interstitial pancreatitis (IP). We evaluated a large cohort of patients with IP and compared data with those from patients with extrapancreatic necrosis (EXPN). Methods: We evaluated 149 consecutive patients with IP admitted over a 2.5-year period. Transferred patients were excluded. We collected data on age, Charlson comorbidity score (CCI), measures of severity on admission or within 24 hours (Acute Physiology and Chronic Health Evaluation II, bedside index for severity of acute pancreatitis scores), persistent (>48 h) systemic inflammatory response syndrome, persistent organ failure, need for intensive care unit, length of hospital stay (in days), and mortality. We also analyzed levels of severity among those with IP and EXPN. Statistical analysis was performed using SAS version 9.1 (Cary, NC). Results: Among the patients with IP, the median CCI score was 1, the median Acute Physiology and Chronic Health Evaluation II score was 7, and the median bedside index for severity of acute pancreatitis score was 1. In addition, the median length of hospital stay was only 4 days; only 1% had persistent organ failure and only 1% to 2% required intervention. The mortality rate of IP was 3%; it was associated significantly with comorbidity (the median CCI scores of nonsurvivors and survivors was 4 and 1, respectively, P = .003). Patients with EXPN had greater levels of disease severity, compared with patients with IP. Conclusions: IP is severe in only 1% to 3% of patients; mortality of IP is associated strongly with comorbidity. EXPN is more frequently severe than IP; EXPN must be distinguished from IP in clinical studies.

Original languageEnglish
Pages (from-to)1098-1103
Number of pages6
JournalClinical Gastroenterology and Hepatology
Issue number12
StatePublished - Dec 2011

Bibliographical note

Funding Information:
Funding This study was supported by a research grant from the National Pancreas Foundation (P.A.B. and V.K.S.).


  • Inflammation
  • Outcome
  • Pancreas
  • SIRS

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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