An efficient synthesis of bis-1,3-(3′-aryl-N-heterocycl-1′-yl) arenes as CCC-NHC pincer ligand precursors

Tyler O. Howell, Aron J. Huckaba, T. Keith Hollis

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A report that demonstrated an efficient methodology for the arylation of imidazoles has been extended to bis(N-heterocyclic) compounds. Using bis(aryl) iodonium salts provides high-yielding access to CCC-NHC ligand precursors in a single step. Examples of arylation using various iodonium salts are reported herein with an investigation into the factors governing their relative rate of reactivity. The metalation of one of these compounds using Zr(NMe 2)4 and its subsequent treatment with [Pt(COD)Cl 2] to yield a transmetalated product are reported.

Original languageEnglish
Pages (from-to)2570-2572
Number of pages3
JournalOrganic Letters
Volume16
Issue number9
DOIs
StatePublished - May 2 2014

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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