An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis

Gerald V. Denis; Barbara S. Nikolajczyk; Gavin R. Schnitzler

doi:10.1016/j.febslet.2010.05.030

An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis

Gerald V. Denis, Barbara S. Nikolajczyk, Gavin R. Schnitzler

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Transcriptional co-activators, co-repressors and chromatin remodeling machines are essential elements in the transcriptional programs directed by the master adipogenic transcription factor PPARγ. Many of these components have orthologs in other organisms, where they play roles in development and pattern formation, suggesting new links between cell fate decision-making and adipogenesis. This review focuses on bromodomain-containing protein complexes recently shown to play a critical role in adipogenesis. Deeper understanding of these pathways is likely to have major impact on treatment of obesity-associated diseases, including metabolic syndrome, cardiovascular disease and Type 2 diabetes. The research effort is urgent because the obesity epidemic is serious; the medical community is ill prepared to cope with the anticipated excess morbidity and mortality associated with diet-induced obesity.

Original language	English
Pages (from-to)	3260-3268
Number of pages	9
Journal	FEBS Letters
Volume	584
Issue number	15
DOIs	https://doi.org/10.1016/j.febslet.2010.05.030
State	Published - Aug 2010

Bibliographical note

Funding Information:
This work is supported by grants from the National Institutes of Health (NCI and NIDDK) , the American Cancer Society and the Leukemia and Lymphoma Society . We thank our colleagues for their elegant and detailed work that explores the transcriptional programs of adipogenesis; space constraints do not permit comprehensive citation. Any omissions and errors are of course our own.

Funding

This work is supported by grants from the National Institutes of Health (NCI and NIDDK) , the American Cancer Society and the Leukemia and Lymphoma Society . We thank our colleagues for their elegant and detailed work that explores the transcriptional programs of adipogenesis; space constraints do not permit comprehensive citation. Any omissions and errors are of course our own.

Funders	Funder number
National Institutes of Health (NIH)
American Cancer Society
National Childhood Cancer Registry – National Cancer Institute
National Institute of Allergy and Infectious Diseases	R01AI054611
National Institute of Diabetes and Digestive and Kidney Diseases
Leukemia and Lymphoma Society

Keywords

Brd2
Mouse model
Obesity
Peroxisome proliferator-activated receptor γ
Switch mating type/sucrose non-fermenting

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.febslet.2010.05.030

Cite this

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title = "An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis",

abstract = "Transcriptional co-activators, co-repressors and chromatin remodeling machines are essential elements in the transcriptional programs directed by the master adipogenic transcription factor PPARγ. Many of these components have orthologs in other organisms, where they play roles in development and pattern formation, suggesting new links between cell fate decision-making and adipogenesis. This review focuses on bromodomain-containing protein complexes recently shown to play a critical role in adipogenesis. Deeper understanding of these pathways is likely to have major impact on treatment of obesity-associated diseases, including metabolic syndrome, cardiovascular disease and Type 2 diabetes. The research effort is urgent because the obesity epidemic is serious; the medical community is ill prepared to cope with the anticipated excess morbidity and mortality associated with diet-induced obesity.",

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author = "Denis, {Gerald V.} and Nikolajczyk, {Barbara S.} and Schnitzler, {Gavin R.}",

note = "Funding Information: This work is supported by grants from the National Institutes of Health (NCI and NIDDK) , the American Cancer Society and the Leukemia and Lymphoma Society . We thank our colleagues for their elegant and detailed work that explores the transcriptional programs of adipogenesis; space constraints do not permit comprehensive citation. Any omissions and errors are of course our own.",

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language = "English",

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AU - Denis, Gerald V.

AU - Nikolajczyk, Barbara S.

AU - Schnitzler, Gavin R.

N1 - Funding Information: This work is supported by grants from the National Institutes of Health (NCI and NIDDK) , the American Cancer Society and the Leukemia and Lymphoma Society . We thank our colleagues for their elegant and detailed work that explores the transcriptional programs of adipogenesis; space constraints do not permit comprehensive citation. Any omissions and errors are of course our own.

PY - 2010/8

Y1 - 2010/8

N2 - Transcriptional co-activators, co-repressors and chromatin remodeling machines are essential elements in the transcriptional programs directed by the master adipogenic transcription factor PPARγ. Many of these components have orthologs in other organisms, where they play roles in development and pattern formation, suggesting new links between cell fate decision-making and adipogenesis. This review focuses on bromodomain-containing protein complexes recently shown to play a critical role in adipogenesis. Deeper understanding of these pathways is likely to have major impact on treatment of obesity-associated diseases, including metabolic syndrome, cardiovascular disease and Type 2 diabetes. The research effort is urgent because the obesity epidemic is serious; the medical community is ill prepared to cope with the anticipated excess morbidity and mortality associated with diet-induced obesity.

AB - Transcriptional co-activators, co-repressors and chromatin remodeling machines are essential elements in the transcriptional programs directed by the master adipogenic transcription factor PPARγ. Many of these components have orthologs in other organisms, where they play roles in development and pattern formation, suggesting new links between cell fate decision-making and adipogenesis. This review focuses on bromodomain-containing protein complexes recently shown to play a critical role in adipogenesis. Deeper understanding of these pathways is likely to have major impact on treatment of obesity-associated diseases, including metabolic syndrome, cardiovascular disease and Type 2 diabetes. The research effort is urgent because the obesity epidemic is serious; the medical community is ill prepared to cope with the anticipated excess morbidity and mortality associated with diet-induced obesity.

KW - Brd2

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KW - Obesity

KW - Peroxisome proliferator-activated receptor γ

KW - Switch mating type/sucrose non-fermenting

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An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this