An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis

Gerald V. Denis, Barbara S. Nikolajczyk, Gavin R. Schnitzler

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Transcriptional co-activators, co-repressors and chromatin remodeling machines are essential elements in the transcriptional programs directed by the master adipogenic transcription factor PPARγ. Many of these components have orthologs in other organisms, where they play roles in development and pattern formation, suggesting new links between cell fate decision-making and adipogenesis. This review focuses on bromodomain-containing protein complexes recently shown to play a critical role in adipogenesis. Deeper understanding of these pathways is likely to have major impact on treatment of obesity-associated diseases, including metabolic syndrome, cardiovascular disease and Type 2 diabetes. The research effort is urgent because the obesity epidemic is serious; the medical community is ill prepared to cope with the anticipated excess morbidity and mortality associated with diet-induced obesity.

Original languageEnglish
Pages (from-to)3260-3268
Number of pages9
JournalFEBS Letters
Volume584
Issue number15
DOIs
StatePublished - Aug 2010

Bibliographical note

Funding Information:
This work is supported by grants from the National Institutes of Health (NCI and NIDDK) , the American Cancer Society and the Leukemia and Lymphoma Society . We thank our colleagues for their elegant and detailed work that explores the transcriptional programs of adipogenesis; space constraints do not permit comprehensive citation. Any omissions and errors are of course our own.

Keywords

  • Brd2
  • Mouse model
  • Obesity
  • Peroxisome proliferator-activated receptor γ
  • Switch mating type/sucrose non-fermenting

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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