γ-Secretase catalyzes the cleavage at the carboxyl terminus of Aβ to release it from the APP. While γ-secretase is a major therapeutic drug target for the treatment of Alzheimer's disease (AD), it appears to be an unusual proteolytic activity, and, to date, no protease responsible for this activity has been identified. Based on studies of APP transmembrane domain (TMD) mutants, it is apparent that there are multiple pharmacologically distinct γ-secretase activities that are spatially restricted and that presenilins (PS) regulate cleavage by γ-secretases in a protease independent fashion. Based on these studies, we propose a multiprotease model for γ-secretase activity and predict that the γ-secretases are likely to be closely related proteases.
|Number of pages
|Annals of the New York Academy of Sciences
|Published - 2000
ASJC Scopus subject areas
- Neuroscience (all)
- Biochemistry, Genetics and Molecular Biology (all)
- History and Philosophy of Science