Abstract
The selective protection of the S-(+)-enantiomer of the Wieland Miescher ketone (2) as the tert-butyldimethylsilyl-protected cyanohydrin 7 and the oxidative cleavage of an α-ketol 8 that was derived from 7 provided a model 10 for the A ring of the taxol (1) possessing the correct C-1 stereochemistry of taxol and functionality suitable for further elaboration.
Original language | English |
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Pages (from-to) | 55-58 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 34 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 1993 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry