The selective protection of the S-(+)-enantiomer of the Wieland Miescher ketone (2) as the tert-butyldimethylsilyl-protected cyanohydrin 7 and the oxidative cleavage of an α-ketol 8 that was derived from 7 provided a model 10 for the A ring of the taxol (1) possessing the correct C-1 stereochemistry of taxol and functionality suitable for further elaboration.
|Number of pages||4|
|State||Published - Jan 1 1993|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry